I have not had a mito energy metabolism problem my entire adult life. That was something "others" had. From 2014 to 2015, I had two rising heavy metals (lead and copper) and didn't get it until testing confirmed it around April of 2015! My energy levels weren't greatly affected by those rising levels, but did have clear symptoms that something was going on. But...when I started to detox...whoa...that's where the major fatigue hit like a rock about 2 1/2 weeks into it. Looking back, either the rising heavy metals had been damaging my mito before I started a detox (with no obvious symptoms before then), or the detox did it very quickly, thus the horrific fatigue within a few weeks into the detox and which lasted the entire five months of the detox. I did an OAT test when I had been detoxing about two months, and there were clear mito issues revealed there. I got on the OAT recommended supplements of CoQ10, l-carnitine, B-vitamins and more. Didn't change anything, tho. Yet, once the detox ended, the fatigue mostly lifted...though I did have to deal with digestive issues caused by the once-high copper. But 2016 has been the pits. There were two MAJOR crashes after activities that I did have the energy to do...followed by a severe crash which caught me by surprise each time, taking weeks to recover from, typical of CFS.. After the second horrible crash this year, I looked into things deeper. i.e. I also have three homozygous NDUFS7 mutations and I wondered if the high heavy metals caused those to start expressing themselves even worse. I also redid the OAT...and bingo, clear issues related to the need for even higher doses of CoQ10. So I purchased liquid ubiquinol, taking 1500-2000 mg daily, and that changed my life within a few weeks. But....after my life changed on the high dose liquid CoQ10, I switched to soft gels CoQ10 along with a much lower dose of the liquid CoQ10....and within a few weeks came my third major crash. I am currently back on liquid CoQ10 only in the higher amounts to see if I can regain that energy I had. But the bottom line here for me is that it appears the high heavy metals did all this to me. And whether the months of buildup, or the detox, did it, I'm not sure. Anyone else see high heavy metals cause/make worse their mito/CFS issues??