I'm confused about this issue. I'd like to take an oil supplement and in fact was taking fish oil, but recently read this by Dr. Cheney: The best EFA ratio for CFS consumption an atypical and surprising choice August 29th, 2009, published in Public Relations The essential fatty acids (EFAs) fall into two main categories known as the omega-3 and omega-6 series which are distinguished by the presence of a double bond at either the third or sixth carbon atom from the methyl-group end of the fatty acid chain which typically numbers 18-22 carbon atoms in length. These fatty acids are essential because the body cannot synthesize a double bond at either the 3-carbon or the 6-carbon positions and because these fatty acids are essential to the synthesis of a range of cell associated autocrine and paracrine hormones known as the eicosanoids. These eicosanoids are responsible for an extremely large range of cell functions without which life is not possible and a derangement of which will cause severe cellular dysfunction and important clinical consequences. The eicosanoids control the pro-inflammatory and anti-inflammatory pathways involved in innate immunity and act as signaling messengers in the brain. Diseases affected by the eicosanoids include cardiovascular disease, stroke, thrombosis, arthritis, asthma, allergies, blood pressure and even cancer. They also also influence diabetes and obesity. The eicosanoid synthesis involves the production of ROS and highly reactive lipid peroxides which can damage cellular DNA and mitochondrial DNA. These systems are highly regulated and can be dysregulated by ingestion of either the wrong ratio or inadequate amounts of EFAs or oxidized EFAs. In this post, we explore the incredible finding that different ratios of omega-3 to omega-6 EFAs appear to produce dramatically different effects on the echocardiographically derived ETM, both positive and negative. Surprisingly, the use of omega-3 EFAs and especially fish oil is uniformly negative (N=10) in CFS but not in controls (N=3). This is not terribly surprising since omega-3 oils are far more easily oxidized and is possibly explained by the more redox impaired status of CFS. However, we are also finding that omega-6 alone, while better than omega-3 alone in an oxidizing state such as CFS, is not nearly as positive as a mixture of the omega-3, omega-6 and omega-9 EFAs. In particular, a ratio of omega-6 to omega-3 of 3:1 appears ideal and generates the most positive ETM response. Such a ratio is found in high grade olive oil but not lower grades of olive oil which are as high as 13:1, omega-6 over omega-3. The use of fish oil as an omega-3 source is inferior to the use of a plant source of omega-3 such as flaxseed oil or possibly a cyanobacteria derived source such as spirulina. As the ratios of six to three approach 1:1, the ETM response becomes more variable in each patient but the 3:1 ratio of omega-six over omega-three is always a good choice if it excludes fish oil. This important finding of large EFA ratio variances in ETM response could be used to great advantage as the regulation of the eicosanoids are very dependent on a proper EFA ratio and this appears especially so for CFS. This means that the entire paracrine and autocrine hormone system involved in eiconasoid regulation can be favorably influenced with the right EFA ratio and this could have profound and positive effects in CFS. Conversely, the wrong EFA ratios could have significant and negative consequences in CFS. So, can anyone recommend an oil thta is effective? Is flaxseed oil the way to go? Thanks.