Hello, are any of you here dealing with similar gene variations? Having done a genetic test has been very revealing to me because I can finally connect the dots with all these things that I never considered before: sulfur, sulfates, ammonia issues, histamine, and all these paradoxical reactions I've been having with supplements. So far, pretty much all supplements and vitamins (except for Magnesium, fish oil) make me more tired and more sleepless. Molybdenum is somewhat helpful and I feel my liver working better but it causes more fatigue. From what I read epigenetics is quote a rabbit hole and navigating all these genetic mutations like MTHFR, CBS, COMT is extremely complicated. Not only I have to find a way to support methylation but also be careful not to aggravate all these CBS and COMT issues. My body is very sympathetic dominant and any supplements I tried before like Methyl B12, SAMe, Biotin and some others make wired and unable to sleep. The only thing I haven't tried is Methyl Folate which I'll try in very slow dosages together with B6, B12 once I recover from my recent spout of insomnia. My biggest priority now is to remove a few silver fillings as I read that all these gene mutations have been implicated in people storing heavy metals like mercury and copper. I was so stupid to have a doc in US talk me into this... BIG MISTAKE. Here's an image with my results. I'm really hoping there is someone here with similar gene variations that have learned how to navigate this well. Would be very grateful for your comments and any sense of direction. I have no docs in my country that understand these things, perhaps I'll have to consult with someone from US via Skype once I know who can be of help.