Hello! I am new here and so grateful for all this information! But there is alot of info here, I have been scrolling through pages and pages of posts. So I apologize in advance if I ask a question that has already been answered. I am 48 yo female with FM. Last year had glutathione infusions and glutathione supporting supplements including NAC. Had frequent UTIs for many years and was treated with a weekly preventative dose of Cipro until I became allergic to it. Don't know what happened in 2005, ran a fever for 4 months, labrynthitis and BPPV, first time on the couch for months at a time. Currently, lots of muscle pain, mainly hips, neck, shoulders, and arms from the elbows down. Joint pain that jumps around from day to day. Treating mental slowness with Choline/Inositol and poor sleep with melatonin and GABA, Naturethroid 225 mcg daily and do all biodentical hormone supplementation creams and 50mg iodoral. Before I found your protocol, I had been taking B-Right 2-3 times a day with other supplements, most of which are your supporting factors. I've tried Sam-e a couple of times because it is so great for pain. The first time I only managed to stay on it a few days because the dosage was way too high - 400 mg, I developed seratonin syndrome. A few weeks ago I started again at 100 mg each day. The effect was fabulous, I felt tremendously energized and could think quickly and clearly for about a week. Then the effect diminished and I felt terrible again. So I only take 100 mg every 3-4 days to help with muscle and joint pain. I do not get the "fabulous" feeling anymore with it. Rather I feel very tired and down on the day I take it, with a dull headache. That is what happened today - but not with the usual headache. I am 12 days into the protocol. I am not supplementing in the recommended order - started with local health food store brand mb12. The next day I was superhuman: energized, my thoughts raced and flew through my head joyfully. I ran on the treadmill, lifted weights, cooked, cleaned and for the first time in a long time, gave thanks continually to be alive. This blessed state continued but decreased slightly each day until today, which has been a very bad day. And I took Sam-e (100 mg) yesterday and today as well, thought maybe now with all the other things in place I might tolerate it. Your recommended supplements came in about day 5 and I added ad12, methyl folate and TMG then. Alot at once I know, but I was not patient at this point in feeling amazing. This is what I'm taking: 1 3000 mcg ad12 morning and afternoon 2 5000 mcg mb12 4 times a day methyl folate 800 mg 2 times a day B-right 1 capsule 2xday 1 scoop TMG morning on empty stomach Sam-e 100 mg (last two mornings, before that every 3-4 days) Potassium 99mg, 1-3 times a day as needed And the supporting cofactors, except aceytl-l-carnitine, have yet to purchase that. 1. Do you have any idea what is going on with the Sam-e? How do I proceed, it helps so much with pain, I want to be able to utilize it. Thank you so much! *****well, I wrote the above last night while waiting to be approved to post in this forum. I was feeling less tired as the evening wore on. Today has been better, feeling more energy clearer thinking and following the protocol except for Sam-E and the afternoon dose of methyl folate. I do have a lingering headache.***** 2. One last question: I was at my doc's today and he gives 1000 unit methyl B12 injections every two weeks. Is this something I could or should work into the protocol?