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Have I missed anything important?

Discussion in 'Genetic Testing and SNPs' started by howirecovered, Nov 23, 2013.

  1. howirecovered

    howirecovered Senior Member

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    My 23andme results came back recently and I ran them through sterling's app. Got some help from @stridor and another friend with interpretation and have posted my research under each relevant section at http://howirecovered.com/my-genetics/

    I'm hoping this info can be helpful to others and also hoping readers may let me know if we've missed anything important.

    I'm 45 and have had CFS symptoms for 30 years or so.. Currently 7 months into methylation support and chelation, all going reasonably well, though by no means easy!

    Thanks for reading :D
    -eric
    Helen likes this.
  2. Helen

    Helen Senior Member

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    @howirecovered

    Hi Eric,

    Thanks for sharing. I wonder if your GSTT1 gene was reported to be present? I think it is very interesting to know if people with mercury-related health problems (I suppose it is mercury you try to chelate?) only do have methylation issues or if they also have mutations in the GST genes. I, and seven others with mercury-related problems, whose gene test results I have seen, do have both. I hope the chelation and methylation protocol will help.
  3. howirecovered

    howirecovered Senior Member

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    thanks for writing Helen! I do have mercury and lead.

    I looked up the raw data on 23 and me and it shows this - does it mean anything to you?
    GSTT1.png
    Last edited: Nov 23, 2013
  4. lnester7

    lnester7 Seven

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    So I am trying to decide which genetic test to get done, I just posted on it. Did you find it helpful? Which test is better to do (23andME or other.....). I know nothing about genetics but I need to tailor my treatment because methilation as is is not doing it for me.
  5. howirecovered

    howirecovered Senior Member

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    I have found it very helpful to have a firmer perspective on my illness and the direction I'm going. It has given me confidence in my strategy to give roughly equal weight to chelation and methylation. Also confidence in the idea of taking substantial quantities of methylation supports. For $99 plus the $20 on sterling's app, I think you can't beat it.
    lnester7 likes this.
  6. lnester7

    lnester7 Seven

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    what are the $20 on sterling's app for??? what is the app for?
  7. howirecovered

    howirecovered Senior Member

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    23andme doesn't do any methylation analysis - just gives you raw data for methylation. You get the analysis from sterling's app.
  8. Sea

    Sea Senior Member

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    Yes, it means you have a significant deletion in that gene, as do I and several others here. Around 15% of Europeans have most or all of that gene missing
    Helen likes this.
  9. Helen

    Helen Senior Member

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    Thanks Sea for the facts.

    @howirecovered, I been taught that this has an impact particularly on the conjugation/binding with these enzymes in the G.I. tract. It might cause a vulnerability to symptoms also from here.
    I think it is important that we think of the two necessary main processes in detoxification. First we have to have a proper methylation to make adequte levels of glutathione. Then we have to have a good binding/conjugating ability with the glutathione-s-transferase enzymes to make use of the glutathione that we actually have at our disposal. If these two processes donĀ“t work properly we seem to be at risk for heavy metal intoxication and other stuff like mold a.s.o.
  10. howirecovered

    howirecovered Senior Member

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    thanks Helen and Sea, very interesting!

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