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Have CBS, COMT but no MTHFR

Discussion in 'Genetic Testing and SNPs' started by phoebe1, Sep 5, 2013.

  1. phoebe1

    phoebe1

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    Hi, I am new here and am looking for some suggestions for B12 supplementation.

    I am homo for:
    MAO-A R297R
    MTR A2756G

    hetero For:
    COMT V158M
    COMT H26H
    VDR Bsm
    VDR Taq
    MTRR A66G
    MTRR A664A
    BHMT-04
    CBS 699T
    SHMT1 C1420T
  2. Valentijn

    Valentijn Activity Level: 3

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    phoebe1 - Due to your MTR and MTRR, B12 supplementation might help. But because of your MAOA, COMT, and VDR, you might have trouble with the extra methyl groups in methylB12. Hence hydroxoB12 might be the safer form to try.

    Your other SNPs listed don't indicate any additional issues.
  3. phoebe1

    phoebe1

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    Ok, great. Thank you, Valentijn.

    Any recommendations for my CBS gene?
  4. Valentijn

    Valentijn Activity Level: 3

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    CBS C699T can't cause the huge problems some people think it can. Since it's heterozygous, you might be a tiny bit slow in getting rid of homocysteine, which could be helped with a normal amount of B6.

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