Like a lot of us, I'm thinking about springing for the 23andme test now that it's so cheap. But, having spent lotsa bucks over 25 years for useless treatments and tests, I am reluctant to get into another round of rigorous supplementation with little or minor result. I've read a lot of posts on the Yasko protocol and on genetic testing and I have yet to see significant numbers of people reporting that this made a real, functional difference for them. Note: I'm speaking of the genetic testing-supplement link, not general methylation protocols where someone is working on the B-12 connection empirically but the testing has not been done. To me it looks like a lot of "sciencey" data about what should be happening, but... So, for those of you who have been actively treating for these SNP's, has there been a functional difference from this?