My DO has recently started me on an adrenal supplement and something called Rhodiola. Now, whether it was just timing I don't know, but ever since starting on the two I have been in severe crash mode. The Friday before taking the supplements for the first time, I had several shots of prednisone and anti inflammatory stuff for pain. By Sunday I was fully crashed and still no relief in sight as I write this. I even skipped two days without taking them to see if I improved, but no dice. So I resumed taking them.