@JaimeS just posted some summaries of CFS studies and this one caught my eye... Metformin increases AMPK activation, so I'm wondering why Metformin isn't rx'ed for CFS patients... Has anyone tried this drug? Did it help w energy levels? thanks. NEWTON ET AL, 2015: Julie Newton and her team discovered that muscle cells of patients with ME had increased myogenin expression but decreased IL-6 secretion in comparison to controls and, when an electrical pulse was sent through the tissue to simulate exercise, muscle cells of ME patients demonstrated impaired AMPK activation and impaired uptake of glucose. Cells responded normally to insulin.