My doc put me on berberine for cholesterol and I started reading up on it and find it does some impressive things. I have not tried it yet because I misplaced the bottle (so many pills, it could be hiding in plain sight - sigh.) But berberine even appears to have effect on allergies: http://www.sciencedirect.com/science/article/pii/S1567576911003067 Berberine inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-κB pathway in mast cells Phil-Dong Moona, In-Hwa Choib, Hyung-Min Kima Thymic stromal lymphopoietin (TSLP) plays a pivotal role in allergic diseases such as atopic dermatitis, asthma, and chronic obstructive pulmonary disease. However, it has not been clarified the effect of berberine (BER) on the production of TSLP yet. Thus, we investigated how BER inhibits the production of TSLP in the human mast cell line (HMC-1) cells. We used enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, luciferase assay, and Western blot analysis to investigate the effects of BER. BER inhibited the production and mRNA expression of TSLP in HMC-1 cells. BER also inhibited the nuclear factor-κB luciferase activity induced by phorbol myristate acetate plus A23187. BER inhibited the activation of caspase-1 in HMC-1 cells. Furthermore, BER inhibited the production of TSLP in primary mast cells. These results provide evidence that BER can help to treat inflammatory and atopic diseases through the inhibition of TSLP. And this one is even MORE interesting! (It may be JUST what I was looking for to prevent any stroke caused by allergies raising PAF): http://www.sciencedirect.com/science/article/pii/S0091674910014235 Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils Ying Song, MD, Chunfeng Qu, PhD, Kamal Srivastava, MPhil, Nan Yang, PhD, Paula Busse, MD, Wei Zhao, MD, PhD, Xiu-Min Li, MD Mast cells and basophils are key effector cells of IgE-mediated anaphylactic reactions. The Chinese herbal formula, food allergy herbal formula 2 (FAHF-2), protects against peanut anaphylaxis in mice. However, the mechanisms underlying this effect are not fully elucidated. Objective To investigate whether FAHF-2 inhibits mast cell/basophil numbers and IgE-mediated activation. Methods Mice with peanut allergy (PNA mice) were treated with FAHF-2 intragastrically for 7 weeks and challenged intragastrically with peanut 1 day and 4 weeks posttreatment. Peripheral blood basophil numbers and peritoneal mast cell numbers and FcεRI expression were determined. Direct effects of FAHF-2 on the murine mast cell line MC/9, and effects of 4 fractions and 3 compounds isolated from FAHF-2 on rat basophilic leukemia cells (RBL-2H3) and human skin mast cells degranulation and on the IgE-mediated spleen tyrosine kinase signaling pathway, were determined. Results Although all sham-treated PNA mice developed anaphylaxis, FAHF-2–treated PNA mice were protected against anaphylaxis after peanut challenge at 1 day and 4 weeks posttherapy. Reduction of peripheral blood basophils began after 1 week of treatment and continued for at least 4 weeks posttherapy. The number and FcεRI expression of peritoneal mast cells were also significantly decreased 4 weeks posttherapy. FAHF-2–treated MC/9 cells showed significantly reduced IgE-induced FcεRI expression, FcεRI γ mRNA subunit expression, proliferation, and histamine release on challenge. Fraction 2 from FAHF-2 inhibited RBL-2H3 cell and human mast cell degranulation. Three compounds from fraction 2—berberine, palmatine, and jatrorrhizine—inhibited RBL-2H3 cell degranulation via suppressing spleen tyrosine kinase phosphorylation. Conclusion Food allergy herbal formula 2 reduction of basophils and mast cell numbers as well as suppression of IgE-mediated mast cell activation may contribute to FAHF-2's persistent protection against peanut anaphylaxis.