When I take supps that give me energy, like b2, NAC, ATP, high doses of mb12, at varying points I run into symptoms that are often described as exitoxicity. For me it starts as a day of feeling noticeably better, then a night of poor sleep. The next days are usually very uncomfortable, with feelings of all my nerves being "exposed" and an emotional anguish that is really hard to describe; it's like a build up of emotions with no reasons behind them. Sleep is nearly impossible and high doses of melatonin are needed. Usually 2-3 days of this is all I can handle and I have to drop which ever supp was causing it. Anyway, I'm wondering if anyone has pushed through this and found benefit in doing so. Or is it just suffering for no benefit?