New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
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has anyone completely lost their ability to feel

Discussion in 'Cognition' started by Aerose91, Feb 1, 2015.

  1. Noellea77

    Noellea77

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    Thanks! How many do you take per day?
     
  2. snowathlete

    snowathlete

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    I have had something like depersonalization for some time, though it is better now I no longer take an anti-depressant. Interestingly, very recently I tried a hypnotic drug which helped me sleep but appeared to massively change my emotional state the opposite way, where i was way way too emotional. Had to stop the drug. I guess maye something like that could help change the balance of gaba/glutamte if thats the problem?

    Although i feel better than i was before i think i still have glutamate hyperactivity so this is interesting stuff - im a bit overwhemed right now but will look into these suggestions myself.
     
  3. Aerose91

    Aerose91 Senior Member

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    I take a b complex called B Minus by Seeking health. My doctor recommended it and coming from Dr Lynch I have to believe it's good. It has all the active forms of the various B's. Just one word of advice, it has a lot of niacin so some days I flush pretty badly. Just keep some methyl b12 on hand just in case.
     
  4. panckage

    panckage Senior Member

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    I know exactly how you feel Aerose. I felt exactly the same things. I could have even written the same post if my grammar was as good as yours ;)

    Anyway I just want to let you know that LDN has fixed all those problems for me including with sex drive. I feel euphoric to be alive again :D
     
  5. Hip

    Hip Senior Member

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    That's very interesting.

    I also developed this emotional flatness (the proper medical name for this is blunted affect) soon after contracting the virus that triggered my ME/CFS, in addition to developing anhedonia (which is closely linked to emotional flatness).

    However, unfortunately I found LDN made my anhedonia worse within a matter of days.

    How long did it take for LDN to fix your emotional flatness?
     
    Last edited: Oct 16, 2015
  6. redrachel76

    redrachel76 Senior Member

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    I also feel like that when I think of the attempts and failures, doubting faces...etc....I can't bring myself to be a cheerleader and have taken a break from trying more treatments. I could fully relate to everything else you wrote too.
    Then when you write "Is there really a redemption coming?" my own thoughts today were "why me?" and not someone else. Then I think about the future.

    I just wanted to say I could totally relate to everything you wrote and I hope you get a "good" day in this illness soon and that we can both feel a little less down about our situation.
     
  7. panckage

    panckage Senior Member

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    I think less than 2 weeks. I also started getting euphoria from kratom and Marijuana again as soon as I started LDN
     
    Hip likes this.
  8. Hip

    Hip Senior Member

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    Wow, LDN seems to have worked very well for you. Did it also improve your ME/CFS symptoms?
     
  9. panckage

    panckage Senior Member

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    Yep most things except maybe energy. I made a post in the last couple days in more detail about it
     
    Hip likes this.
  10. Aerose91

    Aerose91 Senior Member

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    Really happy for you that LDN was so effective. I was actually on it for about a year and saw no effect so i stopped. I hope you continue to progress, though!
     
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  11. heyitisjustin

    heyitisjustin Senior Member

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    I am suffering from both sleep deprivation and depersonalization (although I am used to the latter). My HSCRP is through the roof (although I have normal CRP and cytokines like IL6). It seems like my tryptophan is being converted into kynurenine due to inflammation and I might have high glutamate as well.

    How does one stop the inflammation? Shouldn't I locate it? Does anyone know how to find where inflammation is?
    I've been to several doctors and they've got nothing.

    Are there any tests to verify having high glutamate or high kynurenine/low serotonin/tryptophan?

    NMDA antagonists seem to have different results for me.
    CBD (cannibidiol), lithium, 5HTP+EGCG and NAD boosters seem to help. Mag threonate made my sleep markedly worse. NAC either didn't help or made sleep worse.

    Can anyone think of other NMDA antagonists or neuro antinflammatories?

    I have heard naltrexone might help. Does anyone have experience with naltrexone and sleep/depersonalization?

    Do the people with depersonalization have sleep disturbance/low serotonin? I wonder both are tied to the same inflammation process?
     
  12. Tunguska

    Tunguska Senior Member

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    Adreno isn't posting anymore. I'm starting to become drunk so I'm going to post in his place. He doesn't endorse me posting this.

    You basically can't prevent trytophan going down the kynurenine pathway. That basically amounts to curing the disease.

    You can lower it by lowering cortisol and cortisol's effects on the liver. The biggest amount of kynurenine is generated in the liver by TDO which is cortisol driven (not immune-drive). Even if you can't prevent the IDO conversion by the immune system.

    There's a limited amount of research on this, but it's possible that kynurenine itself (the first in the pathway) causes issues. This is actually solved by exercise (!) which increases the kynurenine -> kynurenic acid conversion. I suspect this is an issue since people with ME/CFS don't exercise. Also, this conversion can be prevented by low glutathione, which is fixed by NAC + glycine + theanine.

    Otherwise, you might be like me and suffer from excessive NMDA antagonism. In part this can be caused by kynurenic acid, which is NMDA antagonist, as well as a cholinergic receptor modulator I forget which (lowers dopamine). Anyway, the only thing that can slow down the kynurenine -> kynurenic acid conversion I'm aware of is COX-2 inhibitors.

    Downstream from that you could have issues with quinolinic acid (niacin precursor) and picolinic acid (zinc absorption factor), but I doubt they affect me so I didn't look that far into them.

    The simplest thing to try for any of this is actually high dose transdermal magnesium chloride. It affects a few of the kynurenine metabolite conversions.

    I might or might not be able to reply to this.
     

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