I wanted to ask if anyone has added low dose lithium orotate into the mix...2.5 mg's per day? Reason I ask is because one of Yasko's videos I saw, she mentioned that low dose LO can help transport B-12 and also to help get methylfolate into the cells. I just added this into my mix yesterday. I suffer from depression as well as constant fatigue. Quite some time ago I tried SJW...first on it's own...then later added low dose LO..2.5mg's...per day. The adding in of LO had a better antidepressant effect for me but in general, SJW made me feel very flat so I knew I wasn't really getting at the root of the problem. SJW on it's own when I tried it made me feel very flat so I knew that symptom wasn't from the LO. Then I stumbled across this forum and all of this makes sense to me based on my history of symptoms and even though I have not done the genome testing I would bet that I have a MTHFR polymorphism. Probably explains my trials and tribulations with a kabillion different AD's I've tried over the past years with no positive results. The only thing that "totally lifted" my depression was years ago when I sleep deprived myself. Certainly not a long term solution because we all need our sleep. I'm currently on Freddd's protocol and the only supp I am missing right now is the l-carnitine fumarate but will be getting that. In addition though I am also doing higher dose of SAM-e along with higher dose of methylfolate. I'm taking 1200 mg's of SAM-e along with 15mg's of methylfolate per day. Trying to tackle this depression. Is it the fatigue causing the depression or the depression causing the fatigue? A chicken and egg scenario no doubt. Just yesterday I bumped it up from 10 to 15mg's. Reason being from other posts I've read I understand that the Deplin trials had a better AD response at 15mg's as opposed to 7.5 mg's so I am trying this dose and had no fears in bumping that dose up because I know I have a high tolerance for many supps. I had no negative reaction from that bump up. Yes I have had healing type symptoms along the way but that increase from 10 to 15mg's I had no negative reaction. I did have negative reaction yesterday when I tried for the first time of bumping my adb-12 up to 10 mg's in the morning. No doubt it was a healing symptom since it made my fatigue and depression worse yesterday but I need to back that back down to 5mg's...atleast for now. It sucks when you have the depression along with the fatigue cause the last thing you want to do is make your depression worse when you already have depression. In any event, I just wanted to know if anyone else has tried and have had any positive response to adding in a low dose of LO, whether it be to help with depression if some of you have that or just helping with your CFS symptoms in general. Thanks for listening.