This may explain
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651670/
'
IDE is reduced by the flavin in complex I, to produce semiquinone species which result in an increased level of reactive oxygen species formation, and it is reduced slowly at the physiological quinone binding site. The rates of both reactions are affected by how IDE partitions between the membrane and the aqueous phases. The “negative” effects of IDE are thus reactive oxygen species production, and the inhibition of physiological quinone reduction, caused by slow IDE product release. The “positive” effects of IDE are that, if Q10 is not sufficiently available, it increases the rate of NADH oxidation and regenerates NAD+, and its high affinity means that it may be more effective at outcompeting an inhibitor or reacting with a damaged binding site.'
I think I caused a huge B2 deficiency by adding all the other B vits, this affected reduction of Idebenone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487815/figure/F2/
'
A second interaction of idebenone with complex I occurs at a non-physiological hydrophilic quinone binding site that overlaps with the flavin mononucleotide (FMN) moiety. Here, the one electron reduction of idebenone yields an unstable semiquinone intermediate (IdBH·). This semiquinone causes the one-electron reduction of oxygen (O2) to superoxide (O2·-), regenerating idebenone'
I never had any issues before I added B vits. I used Idebenone because Cheney used to always recommend it. My life was changed, now I am back in hell.
