Hello everyone; I have been reading this forum for a couple of months but this is my first post. I have multiple autoimmune conditions that are not pretty well controlled with a paleo diet and a dose of IV drugs each month. However, I continue to have issues with severe fatigue, intermittent brain fog, and really bad environmental sensitivities. I have been trying to treat my fatigue for many years using supplements. Last year I came across the mitochondria stuff and decided to try alpha lipoic acid and acetyl-l carnitine (in addition to my vitamin D3, potassium, magnesium, and occasional B multi). I felt an increase in energy within the first day. I didn't realize it at the time, but I was becoming more and more anxious each day. Finally, I had a severe panic attack followed by the development of an absolutely crushing depression. I could barely function. I tried to use the mood cure and other supplements, but could not take the pain. I finally saw a therapist and a doctor and started anti-depressants. One year later I STILL need the antidepressants. I have been reading about the methylation protocols and am waiting for 23andme results. But I am terrified to try any carnitine supplements again. Does anyone have any idea what could have happened to screw my brain up so very badly with those supplements? I had never had depression or anxiety before - and this was a life-threatening case. Thanks so much for any guidance. TL/DR - alpha lipoic acide and acetyl-l-carnitine caused severe anxiety and depression that are still present one year later.