As usual a combination of what I have been experiencing and others reports of experiences and questions brings up this question for me. This is speculative as to effect. Let me explain. Consider that peak absorption of potassium to serum is at 14 hours after consumption. What happens with a <12 hour GUT transit time? I developed a software model for time release medication serum level. Most of these drugs claimed 12-24 hour effective release of medication and often an even longer tail going out to 36 hours I'll describe the original Oxycontin since that is the one I have done the most extensive modeling with. The original Oxycontin released 70% of medication during the first 6 hours, another 20% during the next 6 hours and 10% in the following 24 hours. So what happens to the person with IBS with a GUT transit time of 12 hours? They lose 10% of their dose. This 10% trickle isn't much but it is the series of 4 or so doses all trickling out their last 10% of drug that contributed to the "smoothness" of pain relief. What happens is the shorter the GUT transit time the shorter the effective duration of the medication. A person with 12 hour transit time typically finds that Oxycontin is a 6-8 hour medication, not a 12 hour medication. Perhaps with a short transit time, all sorts of things that would be absorbed after 8 hours are not absorbed. So maybe the hypokalemia is as much from impaired absorption from food as from increased need. When my GUT transit time dove under 24 hours to 8-12 hours I couldn't get enough potassium in me, my intestines were paralyzed from lack of potassium and when I took Reglan, and it started up so everything went rapidly south rather than coming back up as vomit. Even when I did get the potassium barely back up and managed the problem, it was always barely enough. So now with the transit time of 36 hours I no longer am having all the muscle spasms I get with low potassium. The angular cheilitis is fading rapidly. My nerves are not getting worse. So how many nutrients don't get adequately absorbed if transit time is under 36 hours, such as under 12 hours? Then there is the effect of the inflammation itself on absorption. It appears to be one of those cycles that once established feeds upon itself getting worse and worse as nutrients become more deficient making the digestive system work even less well. Does this make sense to any of you? How does this correlate with your experiences?