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Gut microbiota: Microbiota and neuroimmune signalling—Metchnikoff to microglia

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by Sushi, Aug 6, 2015.

  1. Sushi

    Sushi Senior Member Albuquerque

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    adreno, Kyla, SOC and 4 others like this.
  2. shannah

    shannah Senior Member

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    Research from Ireland. Unusual.
     
  3. Ema

    Ema Senior Member

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    Here's a penny summary of the summary:

    Basically they have discovered through studies of germ free mice, that the gut microflora influences the maturation, number, shape and response of the microglia by influencing a number of different genes.

    They checked this by giving normal adult mice an antibiotic cocktail that decimated their intestinal flora and those mice started demonstrating the same features of the microglia as the germ free mice.

    Those effects were able to be reversed when they repopulated their gut flora.

    Then it talks about what components of the microbiome are responsible for these effects and it mentions short chain fatty acids (sodium butyrate, sodium propionate and sodium acetate) in particular even though no receptors have been found in the brain yet.

    This process of the microbiota influencing the microglial cells is crucial during development but also persists into adulthood. And so studying this further should provide interesting avenues for treatment of various disorders.
     
    Helen, A.B., Sasha and 3 others like this.
  4. Sushi

    Sushi Senior Member Albuquerque

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  5. Sidereal

    Sidereal Senior Member

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    Not really. University College Cork is one of the main academic centres in the world doing microbiome research.
     
    Helen, sarah darwins, halcyon and 5 others like this.

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