With the fairly recent widespread diversion on CFS theory of causes and clinical trials focusing on the microbiome, it is only natural to ask, are we getting any closer to finding and treating the culprit(s)? PubMed suggests so. Pigs fed a steady dose of H202 for 10 days developed CFS. http://www.ncbi.nlm.nih.gov/m/pubmed/23365398/?i=7&from=cfs gut H202 is the chemical (hydrogen peroxide) that is secreted by certain microbes, even those thought to be non-pathogenic. A study using 16s rRNA tech on Belgian and Norwegian patients showed altered gut microflora. http://www.ncbi.nlm.nih.gov/m/pubmed/23791918/?i=2&from=cfs gut As its now a known fact that gut issues and inflammation can affect the body as a whole backed up once again by this study. http://www.ncbi.nlm.nih.gov/m/pubmed/23842110/?i=1&from=cfs gut The gut supercedes the viral connection to CFS and has now become the major focus. Lipkin and Hornig are currently conducting a large microbiome study and MEassociation are doing one also, just to name a few. Please post your thoughts and participate in the poll.