Hunting down the cause of ME/CFS & other challenging disorders - Lipkin in London
In a talk to patients in London on 3rd September, Dr. W. Ian Lipkin described the extraordinary lengths he and his team are prepared to go to in order to track down the source of an illness, with examples ranging from autism to the strange case of Kawasaki disease.
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Gut Inflammation In CFS

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by shannah, Oct 13, 2010.

  1. Dolphin

    Dolphin Senior Member

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    Which article? Article in OP is at: http://www.nutritionandmetabolism.com/content/7/1/79
     
  2. redo

    redo Senior Member

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  3. Dolphin

    Dolphin Senior Member

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  4. redo

    redo Senior Member

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    Ahh. I am reading the thread with my cell. Feels kinda like looking at a map through a keyhole. I didn't read the URL the first time. Got it now, thanks.
     
  5. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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  6. Wayne

    Wayne Senior Member

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    Beyond, thanks much for posting this. Here's the abstract:
    ...........................................................

    Abstract
    Chronic fatigue syndrome (CFS) is a debilitating disease characterized by unexplained disabling fatigue and a combination of accompanying symptoms the pathology of which is incompletely understood. Many CFS patients complain of gut dysfunction. In fact, patients with CFS are more likely to report a previous diagnosis of irritable bowel syndrome (IBS), a common functional disorder of the gut, and experience IBS-related symptoms.

    Recently, evidence for interactions between the intestinal microbiota, mucosal barrier function, and the immune system have been shown to play a role in the disorder's pathogenesis.Studies examining the microecology of the gastrointestinal (GI) tract have identified specific microorganisms whose presence appears related to disease; in CFS, a role for altered intestinal microbiota in the pathogenesis of the disease has recently been suggested. Mucosal barrier dysfunction promoting bacterial translocation has also been observed.

    Finally, an altered mucosal immune system has been associated with the disease. In this article, we discuss the interplay between these factors in CFS and how they could play a significant role in GI dysfunction by modulating the activity of the enteric nervous system, the intrinsic innervation of the gut.If an altered intestinal microbiota, mucosal barrier dysfunction, and aberrant intestinal immunity contribute to the pathogenesis of CFS, therapeutic efforts to modify gut microbiota could be a means to modulate the development and/or progression of this disorder.

    For example, the administration of probiotics could alter the gut microbiota, improve mucosal barrier function, decrease pro-inflammatory cytokines, and have the potential to positively influence mood in patients where both emotional symptoms and inflammatory immune signals are elevated. Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patients.
     
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  7. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Bother - it's from 2010 and I already have it. It's been referred to before on here, and a thread about it was posted in 2010 here.

    Maybe a mod could merge the two threads?

    It's always good to resurrect papers like this for people who haven't seen them or the earlier discussions.
     
  8. Kina

    Kina Moderation Team Lead

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    Threads have been merged.
     
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  9. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Great - thanks, Kina.
     
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