There are 3 possible layers you have to cross:
#1 Biofilms
From my countless experiments, lactoferrin (or lactoferrin with xylitol) is the #1 biofilm killer. Careful with it since it is quite strong, you must remove biofilms slowly, only use what you can tolerate. For myself, it was only 1 every 3 days and then slowly built up. As the biofilms are slowly removed then the burden lightens up. Mucous membranes are particularly vulnerable to biofilm such as the gastro, sinuses etc. (Sinus infections are tough to get rid of, most likely due to the biofilm environment). Note that lactoferrin (and lysozyme) are manufactured by the body to combat biofilms and are antibiotic.
#2 Resistance (efflux pumps)
Efflux pumps are one of the methods of resistance. I have spooled through countless remedies. I had a forum participant email me about goldenseal leaf. This is not root but leaf. It has worked wonders, where others failed.
Hemp oil (e.g. Nutiva you buy at Whole Foods etc) has all the cannabinoids except THC and it is cheap ($12) and accessible. Cannabinoids stop antibiotic resistance.
https://www.tapatalk.com/groups/pptu/got-pot-t4323231.html. ** This has been another powerhouse. I take a shot (1oz) or two. Cannabinoids are quite effective.
I would be surprised if these two did not stop resistance.
**you can check the main category which has many articles on resistance
https://www.tapatalk.com/groups/pptu/biofilm-busters-efflux-mdr-f15/
#3 Antibiotic Sensitivity
The last stop is antibiotic sensitivity. This means what substance kills the organism. Not all organisms are the same, diversity exists which means different antibiotics may be required. So pathogen A may respond to antibiotic X but not Y.
There are many broad spectrum herbs such as garlic, black seed, caprylic acid (coconut), neem, pomegranate, black pepper, lemongrass, oregano, marigold tea and a whole bunch of spices.
Chai tea contains 7 or 8 spices that are known to kill organisms and I also use curry powder (Sharwood's) which also contains a plethora of natural antibiotics. Most of these are broad spectrum which means they can address bacteria, protozoa, viruses, fungal/yeast etc.
Collodial silver can be useful for gram negative bacteria and some fungal strains -where it is not as effective for gram positive bacteria or protozoa. Being effective against gram negative is a big plus since gram negatives are more difficult to eradicate.
Better to use broad spectrums that layer one another. In other words, I use goldenseal leaf, hemp oil with caprylic acid, neem, black seed etc.
Note: I had tried some many antibiotics, natural and pharma with limited effect until I addressed the biofilms and the resistance. As I have addressed the infections, I have regained what was lost.
Information is for educational purposes only, please check with your healtcare professional before starting.