When I first had m.e, about 13 years ago now, I met someone else who had had it for some years and was almost "recovered" at that point. She had been a patient of Prof Brostoff in London and he used these brain scans. She had the very same story, her scan showed dramatically different blood flow. She recalled that one day at his clinic there was someone else who was suffering from fatigue, who was just a bit run down and he compared their 2 scans as it showed the difference, dramatically, between fatigue and m.e. So this has been known for a long time, but it has been ignored.