Violeta
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I found this while looking into heat shock protein, endoplasmic reticulum stress, and viruses. One thing CFS and GWI have in common. It may also mean that the heat shock protein inhibition is common to both, too. I wouldn't be able to read it if it weren't in my first language, so I'll try to find interesting parts and put them here.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468676/
"While the etiology of CFS is presently regarded as multifactorial, prior infections—particularly viral infections—are likely major CFS triggers. In support of an infectious culprit, a study of CFS versus control subjects observed elevated titers of PKR protein and interferon, with minimal overlap of values with the control group (Vojdani et al. 2007). Elevated interferon titers were also detected in veterans ill with chronic fatigue associated with the Gulf War (Zhang et al.1999). Interferon administration itself produces fatigue and has been used as model to study CFS (personal communication, J. Jones, CDC)"
If CFS symptoms reflect an impaired Hsp state, then improving the Hsp response should improve the condition. Indeed, a nutraceutical product (ADAPT-232 forte), which combines extracts from three herbs (Eleutherococcus senticosus, Schizandra chinensis, and Rhodiola rosea), raises Hsps in response to exercise. This same agent is effective in reducing fatigue and improving performance in a placebo-controlled trial of patients with CFS
I personally find the combination of lomatium, astragalus and schizandra helpful.
Loss of stress response as a consequence of viral infection: implications for disease and therapy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468676/
"While the etiology of CFS is presently regarded as multifactorial, prior infections—particularly viral infections—are likely major CFS triggers. In support of an infectious culprit, a study of CFS versus control subjects observed elevated titers of PKR protein and interferon, with minimal overlap of values with the control group (Vojdani et al. 2007). Elevated interferon titers were also detected in veterans ill with chronic fatigue associated with the Gulf War (Zhang et al.1999). Interferon administration itself produces fatigue and has been used as model to study CFS (personal communication, J. Jones, CDC)"
If CFS symptoms reflect an impaired Hsp state, then improving the Hsp response should improve the condition. Indeed, a nutraceutical product (ADAPT-232 forte), which combines extracts from three herbs (Eleutherococcus senticosus, Schizandra chinensis, and Rhodiola rosea), raises Hsps in response to exercise. This same agent is effective in reducing fatigue and improving performance in a placebo-controlled trial of patients with CFS
I personally find the combination of lomatium, astragalus and schizandra helpful.
Loss of stress response as a consequence of viral infection: implications for disease and therapy
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