My doctor has prescribed methyl-B12 (5000mcg/mL) and methylfolate (1mg/mL) by injection. He has also prescribed 500mg glutathione/mL and 500mg/mL NAC injections. They are to be taken at staggered intervals. I ordered some AdeCo and LCARF to add.
My genetics are attached to this post. Red means mutated. Yellow means partially functioning. Green means OK, no problems. I know genetics don't tell us everything but I'm posting them with the hope that I could get some guidance from other people's experiences.
When I took the GSH and NAC, I was tired for days. I had instant diarrhea, my bowels completely emptied. I became severely depressed and lethargic, even suicidal. This is not the norm for me. It did not seem to be a herx reaction, which I am very familiar with. I thought maybe refeeding syndrome, but even that didn't explain it.
My MD says that because my detox pathways are mutated, I need GSH and NAC support. When I told him about my reaction to GSH and NAC, he said that my body was likely trying to upregulate itself and I was having refeeding syndrome. However I am concerned that those two are depleting my folate cycle through excretion and methyl trap and I'm therefore defeating the purpose of taking the folate and MeCo everytime I take the GSH and NAC.
Can you offer any guidance, based on my genetics? I have severe fatigue. No nerve damage that I'm aware of, but my immune system is severely down-regulated. I have leaky gut and inflammatory bowel that are resistant to all standard treatments. I've tried literally over 100 alternative treatments for my IBD and nothing has worked. My recent genetics testing has led me here. Their solution is to remove my bowel which I'm not open to. Besides which, if I have a folate cycle problem vis a vis GSH/NAC then surgery will just mask the symptoms until something just as serious starts up down the road.
Any insight you can offer is greatly appreciated... I am pretty much desperate at this point. In advance, I am so grateful for any time/energy you can spare on this. The medical community has not been able to really help me.
@Freddd
My genetics are attached to this post. Red means mutated. Yellow means partially functioning. Green means OK, no problems. I know genetics don't tell us everything but I'm posting them with the hope that I could get some guidance from other people's experiences.
When I took the GSH and NAC, I was tired for days. I had instant diarrhea, my bowels completely emptied. I became severely depressed and lethargic, even suicidal. This is not the norm for me. It did not seem to be a herx reaction, which I am very familiar with. I thought maybe refeeding syndrome, but even that didn't explain it.
My MD says that because my detox pathways are mutated, I need GSH and NAC support. When I told him about my reaction to GSH and NAC, he said that my body was likely trying to upregulate itself and I was having refeeding syndrome. However I am concerned that those two are depleting my folate cycle through excretion and methyl trap and I'm therefore defeating the purpose of taking the folate and MeCo everytime I take the GSH and NAC.
Can you offer any guidance, based on my genetics? I have severe fatigue. No nerve damage that I'm aware of, but my immune system is severely down-regulated. I have leaky gut and inflammatory bowel that are resistant to all standard treatments. I've tried literally over 100 alternative treatments for my IBD and nothing has worked. My recent genetics testing has led me here. Their solution is to remove my bowel which I'm not open to. Besides which, if I have a folate cycle problem vis a vis GSH/NAC then surgery will just mask the symptoms until something just as serious starts up down the road.
Any insight you can offer is greatly appreciated... I am pretty much desperate at this point. In advance, I am so grateful for any time/energy you can spare on this. The medical community has not been able to really help me.
@Freddd