This is fantastic stuff. Grey matter atrophy in the areas of the brain related to sensory and pain processing. I actually would have thought the opposite- because the pain areas in FM are activated; actually the pain enhancing networks are activated and the pain reducing areas are inhibited... But that was a silly conclusion by me because you would expect injury in the areas that weren't working properly and that;s what they found - but only in the pain producing areas - not in those associated with depression :Retro smile: One study found found low grey volume in CFS in the lateral prefrontal cortex. Not sure how that relates to this area...but the anterior cingulate has been a focus in CFS as well by Chaudhuri and Behan - http://aboutmecfs.org/Rsrch/CentralFatigueCFS.aspx Here is the conclusion of the paper I wrote on Central Fatigue This was such interesting work and I think it's been dropped.