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green tea inhibits HIV (could it do the same re: XMRV?)

Discussion in 'XMRV Testing, Treatment and Transmission' started by Rrrr, Aug 6, 2010.

  1. Rrrr

    Rrrr Senior Member

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    i'm posting this just in case HIV and XMRV are similar! (summary: 1-2 cups of green tea per day inhibits cell binding of HIV by 40%) -- rrrr


    http://www.advocate.com/article.aspx?id=39326


    April 12, 2007

    Green-tea study offers hope of AIDS drug

    Health News 2007-04-12 Green-tea study offers hope of AIDS drug Scientists in Texas and the United Kingdom have found that a chemical from green tea reduces HIV's ability to infect cell binding.


    Scientists in Texas and the United Kingdom have found that a chemical from green tea reduces HIV's ability to infect cells.

    The scientists from the University of Sheffield and Baylor College of Medicine in Houston found that as little as two cups of green tea could provide enough of the chemical epigallocatechin gallate (EGCG) to inhibit HIV cell binding by 40%.

    However, they do not recommend that people start drinking gallons of green tea as an HIV preventative. Rather, they are conducting research to find out if EGCG or a chemical like it would make a good HIV drug.

    Epigallocatechin gallate is a catechin, one of a large family of chemicals called bioflavonoids that are found in tea, red wine, and many fruits and vegetables. Most are colored red or purple and/or taste bitter; many have antioxidant properties and have been investigated for some time as possible anticancer and cardiovascular drugs.

    Baylor's Dr. Christina Nance and her team found that EGCG exerts a more direct effect on HIV infection. The molecule likes to bind to CD4, the cell-surface molecule which HIV first binds to as well.

    This was discovered by Japanese scientists in 2003, but by using computers to image the exact shape of the proteins and working out the electronic processes involved, Nance's team worked out that ECGC sticks to exactly the same amino acid (component) of the CD4 molecule as does gp120the "docking module" of HIV.

    "When it binds there, the gp120 envelope proteinand thus HIVcan't [bind]," Nance said. Her team's findings are published in a recent issue of The Journal of Allergy and Clinical Immunology.

    The history of HIV medicine is full of promising-looking compounds from plants that had some effect on the HIV virus in the test tube but, when tested in animals and humans, either produced no effect or only did so at toxic doses. The previous Japanese research had indicated that the same would be true of EGCG -- huge doses would be needed.

    But Nance said that "physiological levels" of EGCG -- that is, 0.2 micromoles per liter, or the amount in just a cup or two of green tea -- inhibited HIV binding by 40%.

    The team is now using computer-imaging tools to examine more closely the way that EGCG binds to CD4 in the hope of developing improved molecules that will bind to it more closely.

    It is also investigating the possibility of a small trial of ECGC in humans to see if it blocks HIV infection in real life.

    If EGCG or something like it does lead to an HIV treatment, it won't be a first. The story of the integrase inhibitors, which has now finally resulted in the launch of a new drug, raltegravir, started when researchers looked at substances derived from green coffee beans.

    And another drug now undergoing trials, bevirimat, was derived from chemicals found in birch-tree bark.

    Will a mug of English Breakfast have the same effect? No. Black tea leaves contain EGCG, but in much lower quantities. That's because black tea leaves are fermented, a process in which many of the catechins are oxidized to darker-colored molecules called theaflavin and thearubigen. (Gus Cairns, Gay.com/U.K.)
     
  2. guest

    guest Guest

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    Just throwing in my 2 cents, if I remember correctly the intake of green tea correlates with increased DHT values. Lots of people with hair loss first thought that green tea decreases DHT values but newer studies claim the opposite. Since testosterone increases XMRV replication this might not be a good thing to do but who knows.
     
  3. dannybex

    dannybex Senior Member

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    Another two cents...

    Green tea, and other teas, are very high in fluoride, which can worsen CFS / fibro symptoms in some folks.

    Perhaps there's no fluoride in ECGC?
     
  4. cfs since 1998

    cfs since 1998 *****

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    Since XMRV infects different types of cells instead of CD4 cells like HIV, ECGC might not be applicable to XMRV.
     
  5. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    So the Fluoride is from the plant material and not the water, correct?
     
  6. guest

    guest Guest

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    Ye, the tea plants grow on soil very high in fluoride. They absorb it and release it when you brew them.
     
  7. Chris

    Chris Senior Member

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    Interesting! though speculative for the time being; AOR and doubtless others make an EGCG supplement that maximizes the focus component without taking in too much fluoride or caffeine (7mg per capsule). Chris
     
  8. FunkOdyssey

    FunkOdyssey Senior Member

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    IMO worrying about flouride or some obscure theoretical DHT concern here is missing the forest for the trees. EGCG is one of the most promising natural anti-viral compounds in existence, in addition to suppressing NF-KappaB and inflammation in general. I don't think it has been tested but I would bet anything a clinical trial of moderate-high dose green tea consumption in a CFS population would show at least some improvement.
     
  9. liverock

    liverock Senior Member

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    I've taken a 400mg EGCG green tea supplement (equivalent to 10 cups of tea) for the last 5 years, but haven't noticed any improvement in symptoms. I started taking it as a prevention against cancer. ECGC is noted as a very good anti-cancer supplement.
     
  10. ukxmrv

    ukxmrv Senior Member

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    I love drinking green tea but haven't noticed any improvement on symptoms. Had a very bad year.

    XMRV+
     

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