HYPOKALEMIA I'm making a quick stop online while on vacation in the mountains. As usual I am learning a few things. I have found a couple of additional triggers for things. I am at a higher altitude than at home by about 2500 feet. This is enough to trigger an adaptive process of making more red cells. Others, here from sea level or other flatlands have as much as a 7500 foot higher elevation than their bodies are used to. Night time muscle spasms, nausea, headaches and other ill effects are commonly reported. Guess what works to stop a lot of these things for many people, potassium. So here we have people who start making more red blood cells as an altitude adaptation who start sufferring from low potassium, again within just a few days of arrival. A potassium supplement rapidly puts an end to it. In the community kitchen for campers Norton Salt substitue (potassium chloride, 600mg/1/4 teaspoon) is readily available. While I noticed that I had to increase my potassium supplement from 1200mg/day to 1800mg/day to hold steady I hadn't asked others about spasms and such supplements. This is not to be confused with altitude sickness which can appear the first few days due to lower oxygen content and generally passes in a couple of days. The low potassium takes several days to appear by which time mild altitude sickness is generally gone if it was present at all. I don't experience altitude sickness at all at only 7500 feet. I have no idea how widespread this is but it has come up with several people, all of whom appear to be have borderline potassium levels at home so this may only apply to those close to hypokalemia in the first place. PARADOXICAL FOLATE DEFICIENCY There is a class of supplements that appears to be becoming more popular, "green" drinks with a great deal of vegetable extracts including vegetable source folate. Green drink "detox" is happening all over the place. Many people suffer the familiar "detox" symptoms which are readily identifiable as paradoxical folate deficincy and readily reversable with Metafolin after quitting the green drink. They think they are "detoxing" their bodies with these things when actually they are inducing Paradoxical Folate Deficiency with high levels of vegetable source folate. This widespread experience of Paradoxical Folate Deficiency by such a large percentage of those taking these drinks leads me to believe that the experience of vegetable folate blocking methylfolate is far more widespread than I had ever thought. Calling a severe induced folate deficiency "detox" and accepting it is dangerous and foolish. I still don't know if there is any real "detox" beyond glutathione/NAC induced folate deficiency, paradoxical folate deficiency and hypokalemia. But these appear to be at least the 90% answers. It could save your life and health to always question "detox" symptoms. So far they are almost always induced folate and/or potassium and/or mb12-adb12 deficiencies and that is very easily demonstrable. The belief in "detox" is a perniciously dangerous belief as real detox, if it exists at all, appears to be far more rare than induced folate/potassium/mb12/adb12 deficiencies. Good luck. I'll be back in a couple of weeks.