Hi all I wonder if any of you science-types have an opinion about this. Background: I've had ME for 7 years and have had some partial remission time, and a seasonally fluctuating pattern (best in spring worst in winter). I have had a long history of allergies (and some new ones since), endometriosis (considered by some to be an autoimmune disease). I know there is a theory about ME causing th1 suppression and th2 dominance, and have been angling for years to get an appointment with an immunologist so I can talk about the wierd seasonal pattern of my ME, discuss th1/th2, maybe try immunovir. Now I have an appointment this week (tomorrow in fact) but ironically in the last couple of months I have suddenly developed Graves' disease (autoimmune hyperthyroid). According to marco's very excellent thread http://www.forums.aboutmecfs.org/sh...-and-Heterogeneity-in-ME-CFS&highlight=immune this is an indication of TH1 dominance not TH2. I'm not all that hopeful about the appointment - too many years of being put in the "too hard basket" by any number of doctors, so I thought I'd ask you guys here what you make of this. I plan to get tested for retroviruses next year (and keeping my fingers crossed) but if I can get something to help in the medeium term that would be great. OTH Ps Having hyperthyroid and ME is rather like having put your foot down hard on both accelerator and brake pedals, You don't go anywhere, but it puts a very big strain on the engine. I'm hoping I can make a 9.30 appt (worst time) by public transport and make sense through hyperthyroid intensity/irritability. Wish me luck!