Red Hot researchers spice up Chilli ME Challenge — Live!
Watch renowned researchers Drs. Ian Lipkin and Mady Hornig take the Chilli ME Challenge, LIVE from New York by webcast this coming Wednesday, 1st July at 1 p.m. EST.
Discuss the article on the Forums.

graphic of antibody's size versus that of a regular drug

Discussion in 'Rituximab: News and Research' started by Sherlock, Jun 18, 2013.

  1. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

    Messages:
    1,229
    Likes:
    663
    Czechosherlockia, USA
    This slide is from the FDA webinar yesterday, which would also happen to give an idea about why the rituximab version called Reditux which is made in India wouldn't be exactly the same as the original Rituxan/Mabthera - it's just too complicated and in fact the number of molecules in either cannot even be exactly measured.

    fda.gif


    http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM356666.pdf
     
    Bob and Sasha like this.
  2. Sasha

    Sasha Fine, thank you

    Messages:
    14,532
    Likes:
    31,218
    UK
    I bet that aspirin feels pretty stupid.
     
  3. SOC

    SOC

    Messages:
    7,803
    Likes:
    16,310
    :rofl: :rofl::rofl:

    aspirin: :sleep:
    rituxan: :ninja:
     
    Bob, Nielk and Sasha like this.
  4. Nielk

    Nielk

    Messages:
    6,356
    Likes:
    8,742
    Aspirin might be the David though against the antibody Goliath.
     
    Sasha likes this.
  5. Sasha

    Sasha Fine, thank you

    Messages:
    14,532
    Likes:
    31,218
    UK

    That's what I'd be saying if I was Aspirin! :)
     
    Nielk, alex3619 and Bob like this.
  6. alex3619

    alex3619 Senior Member

    Messages:
    10,780
    Likes:
    24,615
    Logan, Queensland, Australia
    That protein is a long chain - a string. Its all folded up. What holds it together is a combination of electric charges and new chemical bonds. What do you need to make those chemical bonds? Glutathione. What are we deficient in? Glutathione. What happens if the antibodies are not folding properly? My guess is a loss of specificity leading to a capacity to attack a wider range of targets. Its just speculation but it ties methylation issues to our kind of autoimmune issue.

    Aspirin is an assassin though. It attacks its target and dies in the process. So it really does fit the ninja icon. :ninja:

    Duplicating antibody drugs exactly is indeed extremely difficult. It could be done though, but would require lots more work and genetically engineered B cells or something.
     
    Sasha likes this.

See more popular forum discussions.

Share This Page