Phoenix Rising tells QMUL: release the PACE trial data
Mark Berry, Acting CEO of Phoenix Rising, presents the Board of Directors’ open letter to Queen Mary University of London (QMUL) urging them to release the PACE trial data, and hopes that other non-UK organisations will join British charities in the same request...
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graphic of antibody's size versus that of a regular drug

Discussion in 'Rituximab: News and Research' started by Sherlock, Jun 18, 2013.

  1. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Czechosherlockia, USA
    This slide is from the FDA webinar yesterday, which would also happen to give an idea about why the rituximab version called Reditux which is made in India wouldn't be exactly the same as the original Rituxan/Mabthera - it's just too complicated and in fact the number of molecules in either cannot even be exactly measured.

    fda.gif


    http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM356666.pdf
     
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  2. Sasha

    Sasha Fine, thank you

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    I bet that aspirin feels pretty stupid.
     
  3. SOC

    SOC

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    :rofl: :rofl::rofl:

    aspirin: :sleep:
    rituxan: :ninja:
     
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  4. Nielk

    Nielk

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    Aspirin might be the David though against the antibody Goliath.
     
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  5. Sasha

    Sasha Fine, thank you

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    That's what I'd be saying if I was Aspirin! :)
     
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  6. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    That protein is a long chain - a string. Its all folded up. What holds it together is a combination of electric charges and new chemical bonds. What do you need to make those chemical bonds? Glutathione. What are we deficient in? Glutathione. What happens if the antibodies are not folding properly? My guess is a loss of specificity leading to a capacity to attack a wider range of targets. Its just speculation but it ties methylation issues to our kind of autoimmune issue.

    Aspirin is an assassin though. It attacks its target and dies in the process. So it really does fit the ninja icon. :ninja:

    Duplicating antibody drugs exactly is indeed extremely difficult. It could be done though, but would require lots more work and genetically engineered B cells or something.
     
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