Hi folks... My 23 and Me results are in - listed in my signature. My results are not surprising... as I have symptoms of fatigue, glutathione deficiency, poor methylation. ---- I interpret the MTHFR C667 to mean my folate metabolism is significantly impaired - I need to take methylfolate. (I tried a multivitamin containing methylfolate and high dose B vitamins and I was overstimulated. I am going to try again with a low Bs multi.) I interprets the MTRR A667 and MTR A2756G to mean I have problems with B12 recycling and that I need more B12 than the average person. This site says "You can address the MTRR A66G mutation by taking methyl-B12 supplements, usually in doses of 1,000-2,000 mcg per day. If you have both an MTRR A66G mutation and an MTR A2756G mutation, you may want to consider higher doses, up to 5,000 mcg per day." Questions: 1.) What about MAO-A R297R? 2.) What about the possibility of having CBS / Sulfur / ammonia issues with one hetero CBS mutation and a couple hetero BHMTs? 3.) What does detox mutation CYP2D6 mean? Thank you for any speculative or nuanced "big picture" interpretation of these results!