I have had three rituximab infusions, beginning in May 2012. I have also taken Valcyte beginning June 2012. Beginning September, I started working full time for the first time in my life (I was a teenager when my ME/CFS symptoms began) and have been able to handle 40-45 hours per week, with limited energy to spare for leisure activities. However, I am not symptom free. Five months is about the average time it takes to see improvement with rituximab.