Gnosis has been ordered by the US District Court for the Southern District of New York to correct previous mislabeling and misinformation. "Extrafolate is not a substantially Pure 6S Isomer Product." The Extrafolate products (Extrafolate-S and Extrafolate) turn out to be a Mixture product that consists of appr. 50% of the 6R and 50% of the 6S isomers of methyltetrahydrofolate. 6S is the active isomer, 6R is an unnatural isomer that provides no nutritional benefit. See for yourself what the CEO of Gnosis said (dated March 4, 2013): http://www.gnosis-bio.com/pdf/Letter_Engredia_2013 04-03-2013.pdf As far as I know Gnosis's Extrafolate-S is used in Thornes 5-MTHF 1 mg. Perhaps it's not such a good idea to use that product: Folate racemic MTHFR and folinic may be dangerous, according to the writer of this blog: "The 6R type of folates do NOT occur in our bodies naturally and are stored in the liver. They INHIBIT natural folate (the 6S type of MTHF is inhibted by the 6R type and BOTH types are stored in the liver when taking these racemic supplements. The 6R type appears to be HARDER for the body to dispose of and there appears to be NO known function to it..but it DOES inhibit by blocking the real folate (the 6S type) from being used." Source: http://tealady-health.blog.co.uk/20...-mthfr-and-folinic-may-be-dangerous-11203372/ I got that last link via MTHFR.net: http://mthfr.net/forums/topic/5-mthf-vs-l-5-mthf/ Dr. Ben Lynch, about the link to that article on racemic forms of methylfolate: "I merely am showing it to you as it may actually be useful – or it may be totally worthless." Since this all isn't exactly my area of expertise, I'd like to second that.