Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Glycine/Serine ratio and under/over methylation?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Kimsie, Feb 10, 2016.

  1. Kimsie

    Kimsie Senior Member

    Could the Glycine/Serine ratio could tell us anything about whether a person is over/undermethlyated? I don't think it could be used all by itself, but along with other factors it might give evidence for a person to figure out if they are an over or under methylator.

    Here are the NutrEval results for me and my husband.
    Glycine_serine ratio.jpg
    The ratios go along with what I have suspected to be our methylation type. I think the angle of the red line is more important than the ratio numbers.

    A person could have a high or low ratio and have normal methylation, since so many factors are involved, but if a person has reason to believe that their methylation is not normal, the ratio could give a clue because glycine is used to keep SAMe levels from getting too high, and the glycine/serine ratio affects the direction of the SHMT enzyme which affects the availability of 5, 10 methyleneTHF, which is needed for MTHFR and for thymidlyate synthesis.

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