I can't think of anyone better than Rich. He understood this and many other health related matters beyond methylation better than almost everyone here. You'll have to excuse me if I doubt the accuracy of your "trials". In one of them you claim 100% of the participants experienced adverse effects to glutathione/whey/NAC and that 100% recovered using 8mg dose of Metafolin and 10mg each of adb12 and mb12. There's no way that's possible. I'd be surprised if even 30% had the exact same experience. I know that the methylation dosages vary a lot for each individual so even if I'm to believe that everyone had an adverse reaction to glutathione (which I don't) it is impossible for everyone to everyone to have a complete reversal of symptoms using the exact same dosages of B12 and folate. Many people here would be very sick taking even a fraction of 8000 mcg methylfolate and 10,000 mcg methylcobalamin. In another "trial" you recommend 150,000 mcg methylcobalamin (3 50 mg doses) and multiple 15,000 mcg doses of methylfolate. This is very misleading and dangerous to people just learning about methylation and someone could get very sick if they were to believe this would help their "healing".