Hi Susan, I can't say that I had any effectiveness from folinic acid. 800mcg didn't replace 800mcg of Metafolin and I slowly developed my leading edge folate deficiency symptoms. I have no idea why folinic acid is doing that. I would suggest the Metafolin and cutting the pill. Then we can see what effect it has. I would suggest that you also be taking adb12 and potassium. If the Folinic acid was being effective than you might have depleted something else by starting to heal.