I know that sounds sensible ... but my body is not made of laboratory conditions nor does it live in a laboratory. Start with a single supplement... record results.. oh but that supplement throws one or multiple other reactions out of balance. Is this a bad reaction...? Do i stop the supplement or add in another to balace tbe first out. So now on two supplements... record results... whilst the actual M.E. is fluctuating plus real life factors are fluctuating. Plus initial supplements first OK can become very problematic at any unknown point... delayed toxicity.... is a real factor for M.E. Or it could be a good detox reaction, its really difficult. Unless its something really obvious eg. took pill felt better for four hours and this is repeatable day in day out... its just not an option for me. Plus some supplements need months to give them a proper chance. I did have a peculiar reaction after trying co q10 -( something else a blood test said i was low in) it had 100mg MCT in in a base of spirulina, alfalfa, ... I didnt like it. I felt like it messed with my brain. My dog accidentally knocked the bottle off the counter and all pills were ruined. I have no money to replace as of yet.