Hi all, I reported recently that using the methylation protocal and liposomal glutahtione I was able to get my reduced glutahtione to well within the normal range. My oxidized glutathione also moved to within the nromal range but on the high side. That's all great , however, glutathione is a water soluble antioxidant. So I had my urine isoprostane measured which is a measure of oxidative damage to cell membrane fats which would reflect on my fat soluble antioxidants. The isoprostane is high at 144ng/gCreatinine. Normal is 80-130. My previous result was 172 so a significant improvement but still significant oxidative stress. I will add fat soluble antioxidants (ALA probably and retest). I now think it is important to get fat soluble antixodants as well when doing the methylation protocal.