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Glutathione IV and Nebulized Therapy

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by JasonUT, Jun 16, 2017.

  1. JasonUT

    JasonUT Senior Member

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    Hello,

    My doctors and my nutritionist all agree that Glutathione IV's may be beneficial for me. There is a local clinic that does 2100 mg and 2400 mg Glutathione IV's via slow drip bags. I think each Glutathione IV bag takes about 45 minutes. Does anyone have any experience with this approach?

    Rich VK talks about Glutathione IV's briefly in this article - Augmenting Glutathione in Chronic Fatigue Syndrome (ME/CFS) by Rich Van Konynenburg
     
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  2. Sushi

    Sushi Senior Member Albuquerque

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    I think when you read about patient responses you'll find that it is very individual. Even much smaller doses made me feel horrible. And when I went down to 10 mg with a slow push, I didn't notice any benefit. And, I knew from testing that I was very low in glutathione.
     
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  3. Nickster

    Nickster Senior Member

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    My son did this treatment and it did not work well for him. He was having anaphylaxis issues by the time he did his 4th iv treatment. But, each person responds differently. Best of luck.
     
    Last edited: Jun 16, 2017
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  4. Helen

    Helen Senior Member

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    It migh be an individual genetic problem due to GST SNP´s ( the glutathione-s-transferase enzyme) that prevents the supplemented glutathione to bind to toxins etcetera. I´m not the person to explain, or express, this in English, but knowledgeable people; researchers and also Rich Van Konynenburg who I actually met and discussed this with, pointed to my GST SNP´s in a detoxification gene test and told that they could give me problems as well.

    I think this possibility has been discussed too little here on the forum as it is not only about increasing the glutathione in the body, as it theoretically should be. You also have to have GST enzymes to be able to "make use of" the glutathione in a proper way. Maybe a lack of the GST enzymes could cause severe symptoms from adding high doses of glutathione.
     
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  5. confetti11

    confetti11 Senior Member

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    I've had glutathione by iv many times. No huge differences. I've noticed more detoxifying affect (I think) from nebulizing glutathione. It's cheaper and easier that way for me too. No trip to a doctor's office.
     
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  6. perchance dreamer

    perchance dreamer Senior Member

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    I did quite a few glutathione IVs several years ago, and they really helped my sleep and a little with mood. I didn't have any side effects.
     
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  7. JasonUT

    JasonUT Senior Member

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    @Helen

    ____________________________________________________________________

    The GST SNP is interesting. It appears I have the following via LiveWellO report. What does this mean?
    GSTM1 rs1056806 T CC -/-
    GSTM1 rs2239892 G __ NG
    GSTM1 rs4147565 A -- NC
    GSTM1 rs4147567 G __ NG
    GSTP1 rs1138272 T CT +/-
    GSTP1 rs1695 G AG +/-
    GSTM3 rs7483 T CC -/-

    GSTP1 [ +/- ]
    Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
    _______________________________________________________

    I have a different Gene SNP interpretation report that shows:
    GSTM1 (rs1056806) CC 87.8%
    GSTP1 A114V (rs1138272) 1 CT 14.6%
    GSTP1 I105V (rs1695) 1 AG 44.0%
    GSTs Total 85%
    GSTA1 88%
    GSTA2 80%
    GSTA3 90%
    GSTA4 79%
    GSTA5 100%
    GSTK1 100%
    GSTM1 91%
    GSTM2 80%
    GSTM3 83%
    GSTM4 93%
    GSTM5 83%
    GSTO1 100%
    GSTO2 75%
    GSTP1 85%
    GSTT1 100%
    GSTZ1 43%

    GSTs include the following classes:
    A- (alpha-), P- (pi-), M- (mu-), O- (omega), T- (theta), and Z - (Zeta) These genes encode enzymes that add glutathione to target electrophilic compounds such as therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. All the GST SNPs can be found in the Gene Report. The eznymes GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO1, GSTO2, GSTP1, GSTT1, and GSTZ1 can all be found in the Enzyme Report.

    GSTA2 (rs1803682) CC 100.0%
    GSTA2 (rs60332313) TT 99.9%
    GSTA2 (rs2234951) GG 92.8%
    GSTA2 (rs142078893) CC 100.0%
    GSTA2 (rs2608632) 2 TT 8.8%

    The enzyme encoded by GSTA2 plays a role in the detoxification of electrophilic compounds, including environmental toxins, and products of oxidative stress, by conjugation with glutathione. Variations in this gene can change an individual's susceptibility to toxins. The enzyme encoded by GSTA2 also exhibits glutathione peroxidase activity and thereby protects the cells from reactive oxygen species and the products of peroxidation.
    ________________________________________________________
     
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  8. JasonUT

    JasonUT Senior Member

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    @confetti11

    Nebulized Glutathione sounds very interesting. Can you recommend any articles on the topic?
     
  9. Sushi

    Sushi Senior Member Albuquerque

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    I used to nebulize it together with B12. Rich Van K used to comment on this. If you want to do a Google Site Search, you should find something.
     
  10. Learner1

    Learner1 Professional Patient

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    I have glutathione IVs once a week and they have been helpful.

    However, I'm using them as a part of a mitochondrial support protocol, not by themselves.

    It's usually given with molybdenum at the clinic I go to.
     
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  11. Daffodil

    Daffodil Senior Member

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    @JasonUT my doctor sometimes wants me to do this for a month at a time, twice a week I think. He says to do 600 mg (I think, maybe 800 I cannot remember for sure), which I know is not high at all. The naturopath would often use more.

    I did not really notice much of a difference...maybe the tiniest bit more energy. It is supposed to be very good for our illness. I now take Liposomal gluthatione every morning.

    xo
     
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  12. Daffodil

    Daffodil Senior Member

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    @Learner1 this is the second or third time I have heard of molybedenum...does it help you? One doctor I was talking to, says it helps his patients a lot.
     
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  13. confetti11

    confetti11 Senior Member

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    @JasonUT I'm sorry, I don't know of any articles really. My doctor is an expert of the unusual illnesses and recommended it several years ago. I get it directly from my doctor. I would say I definitely noticed a reaction from it though that I haven't from the IV. I have to do small doses with several days in between.
     
  14. Learner1

    Learner1 Professional Patient

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    Yes, its needed in the transsulfuration pathway, along with taurine and thiamine to help escort toxins out of the body.
     
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  15. ljimbo423

    ljimbo423 Senior Member

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    @Daffodil - Molybdenum is helping me significantly. As @Learner1 said above, I think it's helping to get rid of toxins.

    I've tried to cut back on the dosage a couple of times and each time I do, I get strong, flu-like symptoms within a few hours.
     
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  16. Daffodil

    Daffodil Senior Member

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    @ljimbo423 thanks for letting me know. I am going to ask my doc about it. i remember reading something about it allowing the mitochondria to make energy without oxygen?? or something. sorry bad fog
     
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  17. Helen

    Helen Senior Member

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    I´m sorry but I can´t tell you about your SNP´s and what impact they should have. I was lucky to have experts evaluating mine and telling that there were so many, or significant, that they should affect the detoxification etc. I hope you´ll be able to find that kind of help too.
     
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  18. Groggy Doggy

    Groggy Doggy Building a New Home

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  19. justy

    justy Donate Advocate Demonstrate

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    6 weeks of glutathione IV's at three a week, plus myers cocktails gave me an incredible few months afterwards - the best I have been in 9 years, However it didn't last and due to MCAS I now react to pretty much everything, plus I had to stay away from home to get them as they are way too expensive here.
     
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  20. Learner1

    Learner1 Professional Patient

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    It depends on the problem and how toxic/sick you are.

    I take 1.5g of NAC a day, along with a bunch of methylation nutrients and do a mitochondrial cocktail + Myers cocktail IV followed glutathione once a week and get IV curcumin when it's an emergency.
     
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