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Glutamine versus Glutamate

Discussion in 'General ME/CFS Discussion' started by bdonovan, May 30, 2017.

  1. bdonovan


    A bit of confusion on this one. I had been ramping up the amount of glutamine from None to 10g/day and had been going fine. I was doing so because glutamine helps against leaky gut; repairs the gut's mucosal lining. I have had bad SIBO symptoms; and although anti-biotics and anti-parasitic got rid of it, I want to make sure it doesn't come back and strengthen my gut, as leaky gut may be a root cause or at least a key contributor to SIBO.

    However, I then met with a nutritionist who told me that Glutamine was related to Glutamate and Glutamate caused problems for CFS patients. She told me to stop taking Glutamine which I did. I've noticed a decline in energy (though not sure if it's related to that specifically); my dyspnea (stomach discomfort) has been similar, maybe a tad bit worse since stopping it. It's been about a week and I'm wondering what I should do.

    I know people's reactions to glutamine are all over the map; some get benefit, some get worse. My reaction so far seems to have been positive. I would have thought that if it was negative, I would have felt it by now. Anyhow- provided that I'm one of the people who responds positively to glutamine- should I get back on it or should I heed the concern that long-term there may be more glutamate in my system, which may worsen my CFS?

  2. MeSci

    MeSci ME/CFS since 1995; activity level 6?

    Cornwall, UK
    As you say, people have a range of reactions to glutamine. There are a lot of threads on it, for example this lot:[title_only]=1

    I am currently taking it about once or twice a week - very cautiously. Not sure whether it's good or not...
    bdonovan likes this.
  3. Thinktank

    Thinktank Senior Member

    Europe + Asia
    Not everyone goes berzerk on glutamate. If high glutamate is a concern, then why not add some cofactors to have it help build more glutathione? If l-glutamine is positively adding to your health then i personally see no reason to stop taking it.
    bdonovan, Valentijn and MastBCrazy like this.

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