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"Glutamine is Harmful"...Relationship with Ammonia and Astrocytes.

Discussion in 'General Treatment' started by Ema, Jul 12, 2015.

  1. Ema

    Ema Senior Member

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    Super interesting article...

    Glutamine: A Trojan Horse in Ammonia Neurotoxicity
    http://onlinelibrary.wiley.com/stor...zm&s=3679d7a22fe6be66918c3c6dc74188cc01b535e4

     
    Last edited: Jul 12, 2015
  2. minkeygirl

    minkeygirl But I Look So Good.

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    What do you take to get rid of ammonia?
     
  3. Mary

    Mary Senior Member

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    @Ema - I think the key phrase is " at elevated levels" glutamine can be harmful, and this is true of any nutrient, that it can be harmful at elevated levels.

    Glutamine can also be very beneficial and actually can help remove excess ammonia (http://umm.edu/health/medical/altmed/supplement/glutamine)

    I've been taking glutamine for almost 8 months with no problem.
     
  4. Mary

    Mary Senior Member

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  5. Ema

    Ema Senior Member

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    The dose always makes the poison.

    My point is that it's probably not a good idea to supplement willy-nilly with things like glutamine because they don't always work like they are supposed to in our population.

    Glutamine made me feel much, much worse almost immediately and I've tried it several times. It doesn't help with my elevated ammonia at all and in fact seems to make the symptoms much worse.

    This is probably because I have excessive glutamate. Many with MECFS have dyregulated glutamate and thus should be careful with glutamine, in my opinion.

    I have elevated glutamate, GABA and glycine on neurotransmitter testing as well as elevated ammonia. So clearly something in that pathway is off, for me and many others, that is not solved by pouring more glutamine into the mix.
     
    Last edited: Jul 12, 2015
  6. Ema

    Ema Senior Member

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    AaroninOregon and minkeygirl like this.
  7. halcyon

    halcyon Senior Member

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    I thought I read somewhere that people with ME likely have glutamine deficiency. It's a non-essential amino acid, but it is thought to become conditionally essential during times of injury and illness.

    Perhaps I was thinking about this, which isn't exactly about ME patients but could apply.

    I take around 6g of it a day with no apparent negative effects.
     
  8. Mary

    Mary Senior Member

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    We are all so very different. glutamine is good for me. And I seem to be low in both GABA and glycine, both of which help me with sleep. So what's hurting you is helping me.

    You are right - we shouldn't take things willy nilly, but I think it does a disservice to just state that "glutamine is harmful" in your title. Methylfolate has helped many many people here, and there are many who can't tolerate it, but it would be misleading to do a post stating that it was harmful, period.

    You're providing good information which is important - it's just not the whole story.
     
    whodathunkit likes this.
  9. Ema

    Ema Senior Member

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    It's a direct quote from the paper.
     
  10. Mary

    Mary Senior Member

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    Yes, which talks about elevated levels, not glutamine per se, according to the summary you provided (I tried clicking on your link to the paper but was denied access). That's why your title is misleading. I wish it said "glutamine can be harmful" or "excess glutamine is harmful", something like that.

    Again, elevated anything can be harmful, which otherwise would not be.
     
    South likes this.
  11. Ema

    Ema Senior Member

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    But that's not what the article says. It says it is harmful. It's not (necessarily) my opinion though it does certainly line up with my experience with glutamine.

    I'll add some quotes to the title to clear up that I am quoting directly.

    Thanks for letting me know the link was broken. I always enjoy debating articles with people who haven't actually even read them.
     
  12. Misfit Toy

    Misfit Toy Senior Member

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    I can only give what happened to me which was when I was on Glutamine back in 2013, I found it to cause me intense anxiety. I have high ammonia. I am not sure if it worsened this. I wrote about it a few years ago. I was a mess.

    I think Yucca helps with high ammonia and moly..that's what I have been told, plus charcoal, I believe.
     
  13. AndyPandy

    AndyPandy Making the most of it

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    One dose of glutamine 125mg made me very agitated and aggressive.
     
  14. PeterPositive

    PeterPositive Senior Member

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    Well... poor glutamine, does it deserve all the flak? :D
    It's the only thing that has helped bringing my bowel's secretory IgA from non-existent to the upper range and fighting GI parasites.

    It also seems to have improved the immune system, in general.

    To be honest I've had some insomnia-related issues with the initial doses of Glutamine, so I adopted the usual low-and-slow way for some time, and I got used to it. Currently I am taking 2-3 grams a day with no ill effects.

    If I had to shoot a specific amino acid I'd shoot L-Tyrosine. That's a major anxiety booster for me :ill:

    cheers
     
    Mary likes this.

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