Something very interesting reaction to glutamine and methylation. I have been on methylation protocol for a year but Prior to that tried everything like whey etc. I have been tinkering with methyl folate dose for a Year and finally got up to 5 mg a day because of Lack of results, I have had startup and reactions But stalled on energy and healing. Well I recently started on glutamine to heal my gut And have been hit with huge wave of methylation Startup symptoms as a result. I only have been taking 500mg which is a small dose As some people take 20 grams per day. So I have been doing some research and it says Glutamine can become depleted if you have an Infection, well how about viral ebv and hsv6 for 20 years ?? Anyway, I know I have low glutathione and have tried Cysteine like whey because cysteine is supposed to Be the limiting factor in glutathione production but After failing on whey and failing on methylation But then having huge startup on glutamine, I am starting to think I have massive glutamine Deficiency which is the limiting factor in my Healing because it is holding up glutathione Production as the substrate is lacking. I am starting to think that no matter how much tweaking of methylation factors Like adenob12 or methylfolate or mb12 etc etc. If you don't have enough glutamine you aren't going to Get the reaction to make glutathione going and you Won't heal. I think a lot of people have never considered this because Glutamine is so abundant in your diet and your body can Make it from other aminos but if you have bee sick along Time this might still not overcome it. I am confused why 500mg gives me a reaction considering Normal diet from meat should give 1-6 grams a day, why would 500mg do anything, also could there be a snp limiting glutamine Production ?