heapsreal, I am taking it on an empty stomach in terms of other aminos, as far as I know, but not actually alone. I also take thyroid pills, midodrine and my morning cup of black coffee at this time. Nothing with any calories until an hour or two later.The thyroid pills are best taken on an empty stomach as well, and the midodrine takes 1 1/2 hrs to kick in so I can stand and walk enough to do anything. The coffee I probably don't need to explain! Anyway all these elements seem important to get going first thing. Otherwise, if I spread them all out, my morning pills and schedule would take "forever", and I don't like to be this dominated by pills and an intake schedule.