@Gingergrrl for what its worth, what i have found on antivirals is that although i have improved i still crash, but not as hard or as often so recover much quicker from these and this improves over time. I think we just have to keep plodding along, as if we have a choice lol. But along the way just continue to keep investigating other avenues also and keep trying to find those little things that can give u a few % improvement here and there. I cant really comment on the methylation stuff as i have never really had any positive or negative from them other then some help with b12 injections in the past and currently trying them again now. good luck, keep up with the updates as they may help others down the track learning from your experience as well as yourself. cheers!!