I never had luck with B12 shots. That burst of energy never came. I didn't do methyl folate though with it. Will soon, however. Going to a Sean Bean who worked or trained with Yasko. $350 for first appointment. Usually 3 hours long. Goes over whole 23 and Me and 6 months of tests and your bio. Still have not taken Zantac. Ginger, so glad you have stuck with Famvir. Major thumbs up!