Does anyone know if milk thistle is safe to take when you have Gilberts Syndrome? I've read a lot of sites that say it is but a few say it is not. I read this quote on one site: "Milk thistle is great for liver but not recommended for Gilbert's, because it helps path 1 detoxification and with us who have gilbert's the path/phase 2 is compromised! By promoting phase 1 detoxification it can even put unwanted pressure on the phase 2 which is already impaired." Does this make sense to anyone?