I am +/+ COMT V158M/H62H complicated with +/+ MAO-A R297R and +/- VDR Taq/Bsm. Most of my life I've had most of the neurological symptoms (some severe) that these genes produce in combination. Changing my diet, supplementation and mindfulness meditation have helped immensely but it still seems far harder to think productively and maintain an even mood on a consistent basis than it really ought to be. From what I understand of the mutations (especially as it relates to COMT), the neurotransmitters dopamine, epinephrine and norepinephrine are expressed too heavily in the wrong parts of the brain. Correct me if I'm wrong, but they should be expressed in higher concentrations in the frontal cortex.. Is there any method, food or supplement to help set the brain right? I'm considering trying Seroquel, which supposedly does the job, but I'm not a big fan of prescription meds.