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A Little Poisoning Along the Road to ME/CFS
Looking at my symptoms, many of which are far less these days and some are gone, it would be easy to figure that I'd just been dealing with some heavy-duty menopausal issues.
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Gestalt's Genova, 23andMe & Yasko Methylation genetic results

Discussion in 'Genetic Testing and SNPs' started by Gestalt, Jul 3, 2012.

  1. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Thanks a lot for responding man, this is such an important thing to me, I have come to weight 125 lbs with 5,9 feets tall and I have lots of tests proving lots of my problems are originating in the leaky gut as you discovered by yourself. The brainfog right now its considerable looking at my repeating of the word "lot" I get this word repeating worse when in brainfog and headache right now. I have managed to get some weight back with eating carbs but im still feeling like im wasting away and thats one scary feeling I can tell. Everytime I see someone with some weight I think "now thats health, not this malabsorption syndrome aka autoimmune reactions with most of foods aka Death its around the Corner".

    Anyway, I will start with the Glutamine soon! I only hope I dont die with seizures because of Glutamate cerebral overload lol
     
  2. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Im just about buying the Micronized Glutamine, Pure Advantage brand, Pharmatheutical Grade. Im wondering if I should buy the Japanese Micronized Ajinomoto of Dymatize instead though, but has 200 grams less of Glutamine. Should I take the 15 grams all together or divided in 5 gram doses? Also, using Peptopro or other easily digestible protein its mandatory or not? Did you used that all the way, for how long? Its quite expensive, because for a month suppy the daily dosage would be only 20 grams, so 17 of protein. Its still super neat compared with wasting the money in free form aminos in capsules or seacure which only will provide like 6 grams of protein. But I dont think I need it, I mean, since using digestive enzymes (GB3) my digestion its much better and I think I can get enough aminoacids from meat etc when the leaky gut starts to heal. So the digestive enzymes thing its already covered, the diet, and the metabolic supplements too. I just did things backwards, again :rolleyes:
     
  3. Gestalt

    Gestalt Senior Member

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    It's tough choosing between brands, you want what's the best quality but have no objective way of knowing which one is better or if it even makes a quantifiable difference. Go based on intuition imo. I would take 5g in the morning 5g in the afternoon and 5g at evening before bed, with juice. Sugar supposedly helps absorption. Drink immediately upon mixing. I only took the peptopro when I felt didn't have the stomach acid to digest heavier proteins. If you can digest meat well with digestive enzymes you may not even really need PeptoPro.

    Recently I started using Yasko Amino Acid Spray and the SHMT spray and RNA. People with full SHMT defects (like me); according to Yasko it's considered a priority mutation that often leads to gut issues. The SHMT spray has had a noticeable effect on my gut health. My gut subjectively feels more "hardy". :)
     
  4. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Hmm I still need to decide! But im kinda tilting towards the most expensive (but smaller dosage) and here is why: http://www.amazon.com/Dymatize-Nutr...dp_top_cm_cr_acr_txt?ie=UTF8&showViewpoints=1

    I need to get the good one because my parents are who pay and they have already seen like 35 types of supplements coming into my home and no real improvement. I have also been to naturopaths and specialised docs who charged me much more expensive supplements and therapies (which were the least effective!!?) Its not true that I never got an improvement, but its what they believe. Actually, some supplements made a difference, but wasnt enough to keep buying them. I got rid of my penis pain with an hypoallergenic diet, methylation supplements made my social phobia, joy for life and overall feeling much better until I crashed with a psychotic attack (I speculate that it was the TMG). I never tried Indoplex DIM and even while the guys at my forum of origin we used to chatter about it. That was stupid since I have high estradiol and estriol in all tests. My libido its completely screwed. I cry easily with movies, emotional and estrogenic haha. So thats one supplement I really want to try.

    Yeah if you can afford Yasko supplements its great. I think you are gonna reach 100% recovery since you have the resources and focus to do it. I will get there too, some day ;)
     
  5. Beyond

    Beyond 10% of discount in iHerb!--> PEZ915

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    Bought it! Finally decided to use the most expensive, with feedback. Fingers crossed!! Silver bullet, please do the job for me too! :D
     
  6. xks201

    xks201 Senior Member

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    rs5186(C;C) - 7.3x increased risk of Hypertension

    Perhaps you have high levels of angiotensin 2...try losartan 50mg twice per day.
     
  7. roxie60

    roxie60 Senior Member

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    Thank for such a wonderful thread and all the help you guys provide trying to navigate this maze.
     
  8. roxie60

    roxie60 Senior Member

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    23andME sale as of today (12/11/12). If you been waiting for a sale it is now!!! Good luck
     
  9. roxie60

    roxie60 Senior Member

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    I'm not seeing Glutamine on the methylation pathway, anyone now where it comes into play (is it around the glutamate and GABA area?)
     
  10. roxie60

    roxie60 Senior Member

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    thank you kday, calico and gestalt. kday, is paypal the only option to make a donation right now?
     
  11. kday

    kday Senior Member

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    roxie60 - what option were you looking for?
     
  12. freshveggies

    freshveggies Senior Member

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    I just ran my raw data through genetic genie (i did dontate and thank you) My question. I have the Yasko test in front of me and I am VDR TT ---my raw data says I am AA and acording to genetic genie -/- But Yasko says that TT is homo.
    This is what snedia says:
    VDR Gene
    they say the rist allele is GG. Then why am I AA and Yasko says TT? Is this one just backwards according to what Yasko has figured out?
     
  13. kday

    kday Senior Member

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    The results are identical from what I have seen. I wasn't aware that 23andMe was reportng VDR Fok. The alleles are different, but I'm currently using the official Risk Allele which is G. For Yasko, GG is -/-. I will assume that she doesn't agree with the risk allele on this one. But she made a post somewhere about VDR confusion and how she was going to change the interpretation.

    I have enough evidence that VDR Taq is different from Yasko. And as long as she hasn't swapped the risk allele herself, results will match. I'll make the changes today to match Yasko's.
     
  14. freshveggies

    freshveggies Senior Member

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    The results are identical from what I have seen. I wasn't aware that 23andMe was reportng VDR Fok. The alleles are different, but I'm currently using the official Risk Allele which is G. For Yasko, GG is -/-. I will assume that she doesn't agree with the risk allele on this one. But she made a post somewhere about VDR confusion and how she was going to change the interpretation.

    So Risk Allele for Taq is GG----Why do I come out as -/- and I am a AA in 23 and me? I am just trying to understand and just can't get it. Thanks.

    I don't know if 23 and me has Fok.

    I was thinking for Yasko on Taq -/- is TT she does it backwards for the VDR that is why she does not write in -/- because we would think it is a green and not red?
     
  15. kday

    kday Senior Member

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    I made the changes. A is now the risk allele.

    freshveggies - you come out as AA and -/- because the risk allele was G. Now if you upload your results, you will see the opposite.
     
  16. freshveggies

    freshveggies Senior Member

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    Now I get it.-----Does Yasko just report this backwards and that is why she uses the TT?
     
  17. kday

    kday Senior Member

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    When alleles are different, you can usually swap an A for a T and C for a G.

    So TT=AA.

    And I use the word usually because DNA is double stranded, and the other strand doesn't always match up. But in the case of SNPs, they should match up.

    If you like pictures, maybe this will make more sense.

    [​IMG]
     
  18. freshveggies

    freshveggies Senior Member

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    thank you
     
  19. roxie60

    roxie60 Senior Member

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    Amazon
     
  20. roxie60

    roxie60 Senior Member

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    Thanks guys for pursuing this, this result (AA full defect) now makes more sense given my health experience. I was stunned to have VDR Taq AA and VDR BSM CC be both no variant with original run and I have such difficult time getting my vit D levels just to the low end of the range (taking 5000-10000 / day). Now VDR Taq would be red even though still -/- due to A being the risk allele (provided I am understanding this stuff at all).

    (no data from 23andMe on VDR Fok - I really wish they would add this one and a few of the other methylation SNPs that are missing but they are making progress since it seems version 3 had added some SNPs)
     

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