Now thats a big difference for treatment! That combo of both MTHFRs, CBS, and SHMT, a complete SHMT no less! Do you have leaky gut or digestive problems? I'd have to think you would with all of those! I know the glutamine helped some of that but I'd have to figure you'd be a big risk for bacteria and gut stuff. So, unless your VDRs are normal, it looks like the difference might be 7 or 8 snps from yasko to 23&me? I guess it could be worth it as long as you have normal SHMT and ACAT snps. I say that about the ACAT cuz my girlfriend had 23's done in March and her ACAT was read as normal but when they came back from Yasko last month, it was heterozygous. So 23's ACAT might not be reliable or its a different ACAT snp? Or maybe it was the saliva test vs. blood results, I don't know. But it made a huge difference in her treatment plan since ACAT and SHMT are more important then the others.