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Germany: No evidence of XMRV infection in immunocompromised patients and HIV-positive

Discussion in 'XMRV Research and Replication Studies' started by Firestormm, Feb 22, 2012.

  1. Firestormm

    Firestormm Guest

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    No evidence of XMRV infection in immunocompromised patients and HIV-positive individuals from Germany.

    Infection. 2012 Feb 21. [Epub ahead of print]: http://www.ncbi.nlm.nih.gov/pubmed/22350961

    Abstract

    BACKGROUND:

    Xenotropic murine leukaemia virus-related virus (XMRV) has been detected in patients with prostate cancer and chronic fatigue syndrome (CFS).

    The detection of XMRV in healthy individuals has raised concern about a possible virus transmission by blood products. However, recent studies challenge the association between XMRV and human disease.

    This study investigated whether or not XMRV is present in patients with altered immune function and individuals at increased risk of blood-borne viral infections in Germany.

    METHODS:

    We investigated 503 peripheral blood mononuclear cell (PBMC) samples from 240 patients with iatrogenic immune suppression (71 haematopoietic stem cell recipients, 132 solid organ transplant recipients, 37 others) and 311 PBMC samples from 302 patients with HIV-1 infection for the presence of proviral XMRV by real-time polymerase chain reaction (PCR).

    RESULTS:

    All 814 PBMC samples from 542 patients tested negative for XMRV DNA and positive for an internal herpesvirus saimiri (HVS) control.

    Human genomic DNA was detected in all samples, and 90% of the samples contained >10,000 cell equivalents per XMRV PCR reaction.

    CONCLUSIONS:

    Our failure to detect proviral XMRV provides evidence against the presence of XMRV in patients at increased risk of viral infections in Germany.
  2. currer

    currer Senior Member

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    Can we get the complete paper? because the liklihood is that this is yet another non-replication study, like the other one posted recently, Firestormm, on HIV and HCV patients.
  3. Firestormm

    Firestormm Guest

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    I thought this was the place for XMRV research Currer? If it isn't then I'll ask for it to be deleted. No worries.
  4. currer

    currer Senior Member

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    Why delete it? I just asked to see the whole paper.
    Firestormm likes this.

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