Discussion in 'XMRV Research and Replication Studies' started by bel canto, May 18, 2010.
actually,now I feel guilty for joking about this - the kids issue is a huge concern
Lol, I like the picture you have of Germans
I don't think they would get accused of being sloppy, because they aren't trying to establish a connection between XMRV and CFS! After all, these people were REALLY ill. *irony mode off*
I should have said it's mixed news--good in that someone besides WPI finally found it outside of prostrate cancer. Good that blood isn't the only game in town, good that so few healthy controls tested positive. It's unsettling, though, that the study raises so many issues and questions (as others have noted).
I'll add another "good". It's good that the immunocompromised group (#3) was not infected at rates similar to those found by WPI in CFS patients. By no means conclusive, but this new study seems inconsistent with the notion that immunocompromised people would all have 67% to 98% infection rates. So this further implies that the association found by WPI is more consistent with XMRV => CFS than it is with CFS => XMRV.
The scary implication is what is happening to the immune system of people with CFS. Think about it. There is an increased incidence of 7% of XMRV between people taking drugs to surpress their immune system over the health controls. In the original WPI study in science the number of CFS patients with it was 65% (or there about, too lazy to look). They then said it was actually higher.
That means if you have CFS your immune system is more trashed than a group on immune surpressing drugs. That should get someone's attention...
well seems so but we can't compare these conclusions as they used different methods: possible that wpi tests were more sensitive?
Although the same percentge positive in the control group does suggest your interpretation is correct
that's a big leap, impish - there may be some other factor predisposing cfs patients to infection
however, this definitely should get many people's attention
Your analysis implicitly assumes that the CFS ==> XMRV infection; this is not at all established, and looks less likely all the time (see post #64 above).
No doubt the naysayers will find something to pick on, kicking up some kind of dust cloud to obscure the true implications.
Rrrr, looks like a few more questions for the good Dr. Coffin arise here.
I actually wasn't assuming that CFS causes XMRV infection. I was more looking at it from a worse case scenario. If you were a total sceptic you and were absolutely convinced that XMRV infection results from having CFS and not the other way you still can't say (Wessley, et al) that it is actually related to psychology. If a CFS patients immune system is worse than someone's who is on immune surpressing drugs, CBT is not likely to help them. I don't see large programs offering CBT to people with transplants in order to help their symptoms. You would be laughed at.
Given the fact that viruses in the same family as XMRV (FeLV) cause immune surpression I think it is looking more likely that XMRV is the root cause.
I think we might be looking at XMRV causes immune disfunction in a host. Host gets lots of viruses (which threw people off for years as they thought these viruses might be the cause since they were more visible). Host gets very sick.
If this is the scenario the obvious question is why do some people fight off XMRV and not others? Some sort of genetic factor like the one identified in some people that allows them to not get AIDS even when exposed to HIV?
I really am concerned about transmission, and I hope that more studies come out "pronto" regarding ease/difficulty and modes of transmission. Of course, I also don't know if I am xmrv+. (Maybe I need to get tested first, then worry.) I have worked in a building where there are many people with cancer, many with autoimmune illnesses, and some with cfs type symptoms...
Well, I think it's obviously more likely that immunosuppressed people would have XMRV than people without suprression of the immune system - As it's probably more likely that immunosuppressed people would catch a lot of other bacteria's and viruses... But I don't think that it implies that XMRV is an opportunistic infection in ME/CFS... I mean, immunosupressed people that had the bacteria that causes tuberculosis i n their body before getting immunosupressors have higher chance of getting sick with tuberculosis... Does it say that the tuberculosis bacteria is an opportunistic infection in those who have tuberculosis? Well, it might be opportunistic, but it is the bacteria that causes their tuberculosis.
We might have caught XMRV for various of reasons (for exmple: Genetics or perhaps just bad luck). The immunosupressed people probably caught it more than those who are not on immunosupressors, since, well, their immune system is supressed and they might catch influenza more often too. But it doesn't say that our immune system was supressed before, and than we got XMRV, and that XMRV didn't cause our illnesses. And if the WPI's numbers of about 98% ME/CFS patients that has XMRV are even somewhat close to be correct, and the precentage of healthy people (3.7%) that have it is also somewhat close to be correct, I think it's very very unlikely that XMRV is just an opportunistic infection in people with ME/CFS - Because as you can see people with suppressed immune system get XMRV probably three times more than people with a normal immune system - but not 26.49 more times (which is the proportion between 98 and 3.7).
Am I wrong here people?
Impish: I see your point -- unlikely to be a strictly psychological/psychiatric condition. Good point
omerbasket: that's what I was trying to say, although I think you explained it more thoroughly.
I think you are right. The logic holds. It makes me feel very hopeful for my sister and the others here on the forum. After all of the false hope over the last 25 years I am still having trouble believing it somewhat...
i think it's here Impish, i think we can believe it.
we are lucky, to have what seems to be going to be an answer in our lifetime.
I think you might very well be wrong here. It might just mean that some of these 2-3% of healthy people with XMRV, and 10% of immunsuppressed people with XMRV, might get ME/CFS because of their XMRV (and than the number of ME/CFS patients with XMRV would be 100% - and it might be that it's just 98% in the WPI's study because their methods might not be able to find XMRV whenever it's there, and/or because the 2% didn't have ME/CFS).
This study makes no direct reference to cfs - it does say if you have rti, you are 50% more likely to have xmrv - but still at a low number.
You can't really assume anything about cfs/xmrv from this study. But your point is a good one - how could the correlation with cfs be that high, and so much lower in immunocompromised patients if xmrv is just opportunistic in crs?
So the way I got sick, 18 months ago doesn't sound so improbable huh?
I am a registered nurse, worked with cancer patient, and while starting an IV, I received some droplets of saliva straight into my mouth. Go figure...
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