susan and mitochondria fuels Susan, I did an amino acid profile a few years ago, but it's kind of a waste. I started taking lots of aminos long before I knew it was LG causing everything. I still take lots of them. While people are contemplating or doing their gut fix, there are ways to increase energy considerably by taking the supplements involved in the Krebs cycle. I took all the mitochondria supps I could get my hands on and they got me out of bed. I also took all the neurotransmitter precursors which helped me google for answers. Lots of the supplements intersect and the most important ones for energy and other things are the following. We are deficient in nutrients because digestion isn't working. Look at the supplements as concentrated food. Give the body what it's starving for and it will be able to function better. You can't take everything but this is the minimum. If you just take a few of these you might not get the results you want. I played around with a few things here and there but it was only when I took them all at the same time that I got dramatic results. Mitochondria Mitochondria are rod-shaped organelles that can be considered the power generators of the cell, converting oxygen and nutrients into adenosine triphosphate (ATP). ATP is the chemical energy "currency" of the cell that powers the cell's metabolic activities. This process is called aerobic respiration and is the reason animals breathe oxygen. Without mitochondria (singular, mitochondrion), higher animals would likely not exist because their cells would only be able to obtain energy from anaerobic respiration (in the absence of oxygen), a process much less efficient than aerobic respiration. Incidentally, when your mitochondria are damaged and starved for the chemicals they need and/or your oxygen transport ability of your blood gets too low, the cells will start anaerobic energy production. When you can't move and you're convinced your next breath is going to be your last, this is what is happening. When metabolizing glucose aerobically, the cell's mitochondria obtain 36 ATP's per glucose molecule, but anaerobically, the cells only produce 2 ATP's per glucose molecule. This explains a lot, huh? If your energy can get so depleted that you're floored, you have mitochondrial malfunction. Mitochondria are the sites of respiration, and generate chemical energy in the form of ATP by metabolizing sugars, fats, and other chemical fuels (including coq10, carnitine, ribose, B vitamins and magnesium) with the assistance of molecular oxygen. supps I use for mitos: Krebs Cycle Chelates, a chelated mineral supp by Enzymatic Therapy Country Life Coenzyme B Complex Caps - contains bioactive forms of some B vitamins, this means liver doesn't have to convert them, remember liver is struggling and is responsible for many of our symptoms Coenzyme Q10 - part of the energy cycle, mitos need these and esp the heart which has more mitochondria concentrated there than anywhere else, that's why it keeps beating while the rest of our body crashes - use in gel cap form NOT powdered capsule, is better absorbed that way and this is very important, I was using 100 mg gelcaps up to 6 times per day Magnesium malate, taurate, glycinate are the forms of magnesium to get, they are better absorbed, magnesium oxide is useless, stay away, it's used in laxatives because it passes through the body, crappy vitamins like Centrum and One A Day have it as their sole source of mag, get a good vitamin from the health food store, Source Naturals makes Magnesium Malate which is my favorite - it contains malic acid which helps with the energy cycle, too Alive Whole Food Energizer multivitamin or any good one from the health food store folate - bioactive form of B9, is not the same as folic acid, hard to find, holistichealth has folapro, take 1/4 pill per day to start nadh - involved in energy production, another bioactive form of B vitamin acetyl l carnitine - amino acid involved in energy cycle, bodybuilders use it a lot, I got a lot of tips from bodybuilding websites, acetyl l carnitine is the more absorbable form of carnitine ribose - a sugar made by the body, use caution if hypoglycemic, I was using 5 g in the morning and evening but you could try a few 500 mg pills Biotec Extra Energy Enzymes - these are VERY IMPORTANT! If you take the above substances to increase your ATP production in the mitochondria, you will crash if you don't have your antioxidant enzymes in place to scavenge peroxynitrite and superoxide dismutase - all this according to Cheney - peroxynitrite is such a destructive and dangerous free radical that it can destroy tissue, what happens when we crash (at least a mito crash as opposed to an adrenal crash) is that the body shuts down energy production to stop the production of peroxynitrite which is a byproduct of the energy cycle, the body will shift to anaerobic energy production instead of aerobic - this is when you can't move and feel like you're dying, for a comparison realize that the mitos make 36 ATP molecules per glucose molecule during regular aerobic energy production but only 2 ATPs per glucose molecule during anaerobic energy production, do not skimp on these enzymes, it could cost you a crash and you'll be reluctant to try any more supplements Coenzyme A is another important enzyme in the body and it is involved in the transport of fatty acids into the mitochondria and also to and from cells. Coenzyme A is very unstable and is not available in supplement form. However, the precursors that your body needs to produce Coenzyme A are available. Here's my doses but do your own research at some point: pantethine - vitamin B5 is converted by the body into this form 50mg 3x per day pantothenic acid - is vitamin B5, 150 mg 3x per day calcium pyruvate - 750 mg 3x per day magnesium malate - I get different form of mag from different sources, you want 400-800 mg per day acetyl l carnitine - most easily absorbable and usable form of carnitine, 500 mg 3x per day L cysteine - many people use N Acetyl Cysteine because it is also a precursor to glutathione 250 mg 3x per day or more calcium - I get from different sources, 1000 mg per day glutathione is deficient, too, so take the precursors, no doubt everyone has heard of glutathione by now: NAC, glycine, L glutamate (glutamic acid) - I have amino acid blends that contain the L glutamate and I'm taking NAC and glycine pills, too These supplements should help tremendously with energy and how you feel, I still take many of these. Do not start running around if you feel good, you can still crash if you go past your point of no return. Just pay attention and increase activity very slowly. Sometimes you don't know what you've done until the next day. Keep that in mind. You can only do so much with a quick remedy like this. All of the above are basically harmless, I'm not sure of any drug interactions but I don't think there are any. These are all things that are in a healthy body all the time. I can't experiment for you, you'll have to be your own guinea pig. I started taking most of these all at once except for the Biotec Extra Energy Enzymes, I didn't find out about those for months. There is another brand that uses gliadin for the enzymes - this is the gluten protein molecule - do not use! not worth the risk!